摘要
目的分析2009-2017年山西省晋城市乙型流感病原学特点,为科学防控流感提供依据。方法对2009年8月1日-2017年3月31日哨点医院采集的3 857份流感样病例(ILI)咽拭子,采用实时荧光定量PCR方法检测其流感病毒核酸。收集"中国流感监测信息系统"中ILI监测数据进行分析。结果 8个监测年度检测的ILI样本乙型流感核酸阳性率分别是6. 68%、0. 00%、29. 08%、0. 61%、11. 56%、0. 62%、12. 37%、0. 70%,各年度间差异有统计学意义(χ~2=376. 821,P <0. 05)。2013-2017年4个监测年度,Yamagata系和Victoria系交替出现并分别占主导流行。乙型流感流行季为每年的12月至次年3月。各年龄组的乙型流感阳性率差异有统计学意义(χ~2=153. 350,P <0. 05),其中,6～11岁组阳性率最高,60岁以上年龄组未检出。各年龄组中甲型流感的阳性率均高于乙型流感。除6～11岁组的甲型和乙型流感的阳性率差异无统计学意义外,其他各组差异均有统计学意义(P <0. 05)。8个监测年度的甲型和乙型流感总阳性率差异有统计学意义(χ~2=92. 675,P <0. 01)。不同性别人群的流感阳性率差异无统计学意义(χ~2=0. 014,P> 0. 05)。结论 2009-2017年,晋城市乙型流感呈隔年流行,4个年度中BY系和BV系呈交替流行。各年龄组甲型流感阳性率均高于乙型。小学生为乙型流感高发人群,应进行重点防控。
Objective To analyze the etiological characteristics of influenza B virus in Jincheng of Shanxi province from 2009 to 2017,provide evidence for scientific control and prevention of flu epidemic. Methods Three thousand eight hundred and fifty-seven throat swabs for influenza-like illness（ ILI） were collected from sentinel hospitals between August 1,2009 and March 31 in 2017. RNA of influenza virus was analyzed by using real-time quantitative PCR. And the ILI monitoring data were collected according to the＂Information System for Flu Monitoring＂. Results Positive rates for influenza B virus nucleic acid in the ILI samples during the eight monitoring years were 6. 68%,0. 00%,29. 08%,0. 61%,11. 56%,0. 62%,12.37%,0. 70%,respectively. Differences between each year were statistically significant（ χ~2= 376. 821,P〈0. 05）. From 2013 to 2017,lineages Yamagata and Victoria appeared alternately and became the dominant one. Flu season for influenza B was between December this year and March next year. The positive rates for influenza B were significantly different between different age groups（ χ2= 153. 350,P〈0. 05）. From 6 to 11 years old age group had the highest positive rate while 60 year old age group had zero. In each age group,the positive rates for influenza A virus were always higher than those for influenza B virus. Except for the from 6 to 11 year old age group,the differences in the other age groups were statistically significant（ χ2= 153. 350,P〈0. 05）. The total positive rates for influenza A virus and influenza B virus between different years were significantly different（ χ2= 92. 675,P〈0. 01）. No significant difference（ χ2= 0. 014,P〉0. 05） was detected between different sexual groups. Conclusion The flu B epidemic appears in Jincheng every other year from 2009 to 2017. BY and BV lineage alternates during the four-year period. The disease rate for influenza B is higher than that of influenza A in all age groups.Pupils at elementary schools are the highest hits for influenza
作者
王静
张国平
张玉涵
牛俊国
WANG Jing,ZHANG Guo-ping,ZHANG Yu-han,NIU Jun-guo(Jincheng Municipal Center for Disease Control and Prevention,Jincheng,Shanxi 048000, China)
出处
《中国公共卫生管理》
2018年第5期617-620,共4页
Chinese Journal of Public Health Management
关键词
乙型流感
病原学
核酸检测
influenza B
etiology
nucleic acid detection
