摘要
嗜酸粒细胞性支气管炎（EB）是慢性咳嗽的常见病因，约占慢性咳嗽的10%～30%。EB具有与哮喘类似的气道嗜酸粒细胞炎症，但缺乏气道高反应性和气流阻塞，炎症细胞的种类、浸润部位和气道重塑可能是两者不同的机制。激素治疗反应良好，治疗后咳嗽可缓解甚至消失，但半数以上患者治疗缓解后会复发。EB不是慢性阻塞性肺疾病或哮喘的前期阶段，而是一种独立的疾病。本文就嗜酸粒细胞性支气管炎现状及病理生理研究进展作一综述，以提高对该疾病的认识及确诊率，提高预后和生活质量。
Eosinophilic bronchitis （EB） is an important cause of chronic cough, accounts for about 10%～30% of chronic cough. EB shares a similar eosinophilic airway inflammation to asthma, but lack of airway hyperresponsiveness and airflow obstruction. The different types, infiltration of inflammatory cells and airway remodeling may be the mechanisms which differ from asthma. The treatment of corticosteroids responded well, after treatment, the cough could relieved even disappeared, but more than half of the patients relapsed. EB is highly likely to be a distinct entity rather than an early stage of asthma or chroic obstructive pulmonary disease（COPD）. In this paper, the progress on status of eosinophilic bronchitis and its pathophysiology are reviewed, which should be paied attention to the diagnosis, to improve the prognosis of EB, and to improve quality of life.
作者
史晓凤
陈卫强
万滢
潘晓莉
蒋泽娟
Shi Xiaofeng ,ChenWeiqiang, Wan Ying, Pan Xiaoli, Jiang Zejuan.(Department of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China)
出处
《国际呼吸杂志》
2018年第20期1592-1596,共5页
International Journal of Respiration
关键词
嗜酸粒细胞性支气管炎
慢性咳嗽
气道炎症
细胞因子
炎症介质
气道重塑
Eosinophilic bronchitis （EB）
Chronic cough
Airway inflammation
Cytokines
Inflammation mediator
Sirway remodeling
