摘要
目的分析孕早期母亲双酚A暴露与学龄前儿童睡眠问题之间的关联。方法研究对象来源于中国安徽出生队列中马鞍山市出生队列。调查孕妇基本情况及学龄前儿童睡眠信息。选取于2012年12月至2014年1月检测了母亲孕早期血清双酚A浓度的学龄前儿童，最终纳入1 259对母子。母亲孕早期双酚A浓度以P25、P75划分为低、中、高暴露组，运用多因素多项式logistic回归模型分析母亲孕早期双酚A暴露与学龄前儿童睡眠相关问题的关联。结果孕早期血清双酚A暴露水平P50（P25-P75）为0.231（0.106-0.512）ng/ml。1 259名学龄前儿童睡眠相关问题得分为（16.43±3.82）分；偶尔有睡眠相关问题检出者占47.8%（602名），经常有睡眠相关问题检出者占18.3%（230名）。调整学龄前儿童性别、年龄、BMI、睡觉姿势（趴睡、仰睡）、入睡时长和夜间睡眠时长等混杂因素后，与双酚A低暴露组相比，母亲孕早期双酚A高暴露组学龄前儿童偶尔发生睡眠相关问题的OR（95%CI）值为1.44（1.01-2.06）。按照性别分层分析结果显示，与双酚A低暴露组相比，母亲孕早期双酚A中、高暴露组学龄前女童偶尔发生睡眠相关问题的OR（95%CI）值分别为1.61（1.05-2.46）、2.40（1.42-4.04）；母亲孕早期双酚A高暴露组学龄前女童经常发生睡眠相关问题的OR（95%CI）值为2.64（1.34-5.17）。而在男童中母亲孕早期双酚A暴露与睡眠相关问题之间的关联均无统计学意义（P〉0.05）。结论母亲孕早期双酚A暴露与学龄前儿童发生睡眠相关问题有关。
ObjectiveTo analyze the association between maternal bisphenol A exposure during early pregnancy and sleep problems among preschool children.MethodsResearch subjects were from one of the sub-cohorts（Ma＇anshan Cohort） of the China-Anhui Birth Cohort Study （C-ABCS） in Ma＇anshan city. The basic situation of pregnant women and sleep information of preschool children were investigated. We selected preschool children whose mother＇s maternal serum bisphenol A concentrations of the first trimester had been already detected between December 2012 to Januray 2014. 1 259 pairs of mothers and children were included. The concentrations of bisphenol A exposure during early pregnancy were divided into low, medium and high exposure groups according to 25th percentile （P25） and 75th percentile （P75） levels. Multivariate multinomial logistic regression model was used to analyze the association between maternal bisphenol A exposure during early pregnancy and sleep-related problems in preschool children.ResultsThe P50 （P25-P75） of serum bisphenol A exposure level during early pregnancy was 0.231 （0.106-0.512） ng/ml. The sleep-related problems scores of 1 259 preschool children were （16.43±3.82） points. The occasional sleep-related problems were detected about 47.8% （602 cases） and frequent sleep-related problems were detected about 18.3% （230 cases）. After the adjustment of the confounding factors such as children＇s gender, age, BMI, sleep position （lying down, sleeping on one＇s back）, the length of time to sleep and the length of sleep at night, in comparison with bisphenol A low exposure group, the OR （95%CI） value of preschool children with occasional sleep-related problems in maternal bisphenol A high exposure group during early pregnancy was 1.44 （1.01-2.06）. After the gender stratification, the results showed that in comparison with bisphenol A low exposure group, the OR （95%CI） value of preschool girls with occasional sleep-related problems in maternal bisphenol A
作者
张秋凤
鲍慧惠
吴皖珂
严双琴
盛杰
许媛媛
顾春丽
黄锟
朱鹏
曹慧
苏普玉
陶芳标
郝加虎
Zhang Qiufeng;Bao Huihui;Wu Wanke;Yan Shuangqin;Sheng Jie;Xu Yuanyuan;Gu Chunli;Huang Kun;Zhu Peng;Cao Hui;Su Puyu;Tao Fangbiao;Hao Jiahu(Department of Maternal,Child and Adolescent Health,School of Public Health,Anhui Medical Universit;Anhui Provincial Key Laboratory of Population Health and Aristogenics,Hefei 230032,China)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2018年第10期1018-1022,共5页
Chinese Journal of Preventive Medicine
基金
国家自然科学基金（81573164、81072310）
关键词
儿童
学龄前
睡眠障碍
孕早期
双酚A
Child
preschool
Sleep disorders
Early pregnancy
Bisphenol A
