摘要
目的探讨围手术期抗生素的选择在预防经直肠超声引导下前列腺穿刺活检术后感染的临床作用。方法选取2016年7月～2017年4月诊治的怀疑为前列腺癌的患者186例作为研究对象,将其随机分为A组和B组,所有患者均采取经直肠超声引导下前列腺穿刺活检。A组患者围手术期应用喹诺酮类药物+甲硝唑;B组应用三代头孢+β内酰胺酶类药物。术后1周随访观察感染发生率。结果 A组发生感染19例,占20.4%;B组发生感染4例,占4.3%;两组比较差异有统计学意义(P <0.05)。感染症状表现为菌尿、发热、会阴部疼痛及下尿路症状;病原学检查主要以大肠埃希菌为主,且对喹诺酮类药物有很高的的耐药性。结论经直肠超声引导下前列腺穿刺活检中选择敏感抗生素应用可以显著降低术后感染的发生率,安全可靠。
Objective To explore the effect of perioperative antibiotic selection on infection after transreetal prostate biopsy. Methods 186 patients with suspected prostate cancer from July 2016 to April 2017 were selected as research target, and they were divided into A group and B group, all patients were taken transreetal ultrasound guided prostate biopsy. A group was given quinolones and metronidazole during perioperative period,B group was given third-generation eephalosporin and β laetamase. The infection ineidenee was observed at 1 week after operation. Results 19 eases with infection in A group, 20.4%.4 eases with infection in B group,4.3%, the difference between the two groups was statistieally signifieant（P 〈 0.05）. Symptoms of infection were baeteriuria, fever, perineal pain, and lower urinary tract symptoms. Pathogenic examination based mainly in Eseheriehia eoli, And it had high resistance to quinolones. Conclusion Sensitive antibiotics in prostate biopsy guided by rectal ultrasound can signifieantly reduee the ineidenee of postoperative infeetion, it is safe and reliable.
作者
郝东方
张峰
HAO Dongfang;ZHANG Feng(Urology Department,Central Hospital of ZiBo,Shandong Province,Zibo 255000,China;Surgical department,Zibo High-tech Zone Maternal and Child Health Hospital,Shandong Province,Zibo 255086,China)
出处
《中国医药科学》
2018年第19期217-219,250,共4页
China Medicine And Pharmacy
