摘要
目的 探讨别嘌醇治疗高尿酸血症对慢性肾功能不全患者肾功能的影响.方法 选择2015年2月至2017年8月浙江省杭州师范大学附属医院收治的高尿酸血症合并慢性肾功能不全患者100例为研究对象,将患者按随机数字表法分为观察组和对照组,每组50例,观察组患者在治疗中使用别嘌醇进行治疗,对照组患者则不使用别嘌醇,对两组患者在治疗前后的临床指标进行比较分析.结果 观察组患者治疗前后平均动脉压（MAP）[（102.8±22.2）mmHg比（103.8±19.6）mmHg]、24 h尿蛋白[（2.5±1.4）g/d比（2.5±0.8）g/d]、血红蛋白[（121.7±20.5）g/L比（120.7±26.9）g/L]、CRP[（6.8±1.9）mg/L比（6.4±2.0）mg/L]差异均无统计学意义（t=1.253、0.223、1.052、1.324,均P〉0.05）,血尿酸[（449.8±154.7）μmol/L比（344.6±124.7）μmol/L],血肌酐[（147.8±53.4）μmol/L比（3160.2±51.9）μmol/L]和eGFR指标值（44.4±17.6）比（341.8±22.4）在治疗后均较治疗前有所改善,治疗前后相比差异有统计学意义（t=18.632、25.632、5.062、8.534、10.547、12.635,均P〈0.05）;观察组与对照组患者MAP[（103.4±19.5）mmHg比（3105.8±23.2）mmHg]、24h尿蛋白[（2.4±1.2）g/d比（32.4±1.2）g/d]、血红蛋白[（120.8±22.4）g/L比（3119.4±25.8）g/L]和CRP[（6.8±2.5）mg/L比（36.2±1.8）mg/L]在治疗前、后差异均无统计学意义（t=0.256、0.522、1.635、0.362,均P〉0.05）,血尿酸[（468.7±114.9）μmol/L比（3524.8±118.9）μmol/L]、血肌酐[（142.33±50.2）μmol/L比（3182.3±63.2）μmol/L]和eGFR[（44.7±14.5）比（337.2±21.8）]在治疗前相比差异无统计学意义（P〉0.05）,治疗后观察组患者血尿酸（344.6±124.7）μmol/L、血肌酐（160.2±51.9）μmol/L,显著低于对照组的（524.8±118.9）μmol/L、（3182.3±63.2）μmol/L,eGFR值（41.8±22.4）显著高于对照组的（37.2±21.8）,两组治疗后相比差异均有统计学意义（t=10.635、26.352、8.041,均P〈0.05�
Objective To explore the effect of allopurinol on renal function in hyperuricemia patients complicated with chronic renal insufficiency.Methods From February 2015 to August 2017,100 hyperuricemia patients complicated with chronic renal insufficiency in the Affiliated Hospital of Hangzhou Normal University were selected as the study object,and they were randomly divided into observation group and control group according to the digital table,with 50 cases in each group.The observation group was treated with allopurinol,and the control group was not used allopurinol,The clinical indexes of the two groups before and after treatment were comparatively analyzed.Results The MAP[（102.8 ±22.2）mmH vs.（103.8 ±19.6）mmH],24h urinary protein[（2.5 ±1.4）g/d vs.（2.5 ±0.8）g/d],hemoglobin[（121.7 ±20.5）g/L vs.（120.7 ±26.9）g/L] and CRP[（6.8 ±1.9）mg/L vs.（6.4 ±2.0）mg/L] index in the observation groupbefore and after treatment had no statistically significant differences（t=1.253,0.223,3.1.052,1.324,all P〉0.05）,the serum uric acid [（449.8 ±154.7）μmol/L vs.（344.6 ± 124.7）μmol/L],serum creatinine[（147.8 ±53.4）μmol/L vs.（160.2 ±51.9）μmol/L] and eGFR[（44.4 ± 17.6）vs.（41.8 ±22.4）] were improved after treatment compared with those before treatment,and the differences were statistically significant（t=18.632,25.632,5.534,10.547,12.635,all P〈0.05）.Of the observation group and control group,the MAP were（103.4 ±19.5）mmHg,（105.8 ±23.2）mmHg,respectively and the 24h urine protein were（2.4 ±1.2）g/d,（2.4 ±1.2）g/d,respectively,and the hemoglobin were（120.8 ±22.4）g/L,（119.4 ± 25.8）g/L,respectively,and the CRP were（6.8 ±2.5）mg/L,（6.2 ±1.8）mg/L,respectively.and before and after treatment,there were no statistically significant differences（t=0.256,0.522,1.635,0.362,all P〉0.05）.The levels of serum uric acid [（468.7 ±114.9）μmol/L vs.（524.8 ±118.9）μmol/L],serum creatinine [（142.33 ± 50.2）μmol/L vs.（182.3 ±63.2
作者
项捷
危静
Xiang Jie;Wei Jing(Physical Examination Center,the Affiliated Hospital of Hangzhou Normal University,Hangzhou,Zhejiang 310015,China)
出处
《中国基层医药》
CAS
2018年第19期2497-2500,共4页
Chinese Journal of Primary Medicine and Pharmacy
