摘要
目的探究20例抗N-甲基-D-天冬氨酸受体脑炎的临床效果。方法选取2015年5月至2018年5月接收的20例抗N-甲基-D-天冬氨酸受体脑炎患者为本研究的对象,对其临床特点、预后情况进行回顾性分析。结果临床资料发现,20例患者中有6例患者存在前驱感染史,癫痫、精神行为异常为常见的首发症状。常见症状包括3例发热、2例头痛、5例精神行为异常、4例癫痫、2例意识障碍、1例自主神经症状、1例椎体外系症状、2例睡眠障碍;全部患者经脑脊液检查,发现3例免疫球蛋白异常、2例细胞数异常;MRI显示,有2例头核磁共振呈异常状态,7例脑电图呈异常状态。结论抗N-甲基-D-天冬氨酸受体脑炎患者的临床表现形式多种多样,十分复杂,临床医师需要紧密结合其临床症状、体征状况以及相关辅助检查进行综合分析,最大限度地降低其误诊、漏诊率,提高诊断准确率,为临床治疗提供有价值的依据。
Objective To investigate the clinical effects of 20 cases of anti-N-methyl-D-aspartate receptor encephalitis. Methods Twenty patients with anti-N-methyl-D-aspartate receptor encephalitis received from May 2017 to May 2018 were enrolled in this study. The clinical features and prognosis were retrospectively reviewed. analysis. Results Clinical data revealed that 6 of 20 patients had a history of pre-infection. Epilepsy, abnormal mental behavior is a common first symptom. Common symptoms included 3 cases of fever, 2 cases of headache, 5 cases of mental behavior abnormalities, 4 cases of epilepsy, 2 cases of disturbance of consciousness, 1 case of autonomic nervous system, 1 case of extracorporeal system, and 2 cases of sleep disorder. All patients were examined by cerebrospinal fluid, and 3 cases of immunoglobulin abnormalities were found, and 2 cases were abnormal. MRI showed that there were abnormalities in the head NMR of 2 patients, and the EEG of 7 patients was abnormal. Conclusion The clinical manifestations of patients with anti-N-methyl-D-aspartate receptor encephalitis are diverse and complex. Clinicians need to closely combine their clinical symptoms, physical signs and related auxiliary examinations for comprehensive analysis. The limit reduces the rate of misdiagnosis and missed diagnosis, improves the diagnostic accuracy, and provides a valuable basis for clinical treatment.
作者
吉木舍
李春阳
Jimushe;LI Chun-yang(Neurology,Inner Mongolia Medical University Affiliated Hospital,Hohhot,Inner Mongolia 010017)
出处
《智慧健康》
2018年第26期56-57,共2页
Smart Healthcare
