摘要
目的分析神经性厌食症(AN)患者血象和骨髓象特征,探讨其在AN诊断及疾病发展中的意义。方法回顾性分析本院1993年-2014年诊断的11例AN患者资料,比较AN患者外周血细胞计数,观察红细胞形态,分析其骨髓细胞学和组织学特征。结果 11例AN患者血象均表现为轻度、中度贫血伴锯齿状红细胞增多;骨髓穿刺液均呈胶冻样不易推片,镜检呈均一性浅红色,骨髓象示有核细胞减低,部分缺铁但无小细胞低色素性特点;骨髓活检缺乏坚固的圆条形软组织,且不易获取,造血组织降低但无脂肪组织增加,且均见多少不一的匀质性变性成分。结论 AN所致的骨髓造血功能衰退具有特殊性,动态观察AN患者血象和骨髓象变化既可以协助诊断,又可以评估AN患者病情严重程度,为临床诊断和治疗提供依据。
Objective To analyze the features of blood and bone marrow in patients with anorexia nervosa（AN） and to explore its significance in the diagnosis of AN and disease progression. Methods The clinical data of 11 AN patients diagnosed from1993 to 2014 in our hospital were retrospectively analyzed. The peripheral blood cell counts of AN patients were compared,the morphology of erythrocytes were observed,and the bone marrow cytology and histology were analyzed. Results The peripheral blood of 11 patients with AN all showed mild and moderate anemia with serrated erythrocytes. The bone marrow aspirates were not easily pushed by jelly,and were homogenized by light microscope. The bone marrow showed a decrease in nucleated cells,with iron deficiency but no characteristics of small cell hypochromic; bone marrow biopsy was lack of solid round bar soft tissue,and difficult to obtain,with hematopoietic tissue reduction but no increase in adipose tissue,and varying degrees of homogeneity of the degenerative components were seen. Conclusion The decline of bone marrow hematopoietic function induced by AN is of particularity. The dynamic observation of the changes of blood and bone marrow in patients with AN can not only help diagnose but also assess the severity of AN patients,which can provide basis for clinical diagnosis and treatment.
作者
孟兴法
杨军军
卢兴国
俞建良
MENG Xing-fa;YANG Jun-jun;LU Xing-guo;YU Jian-liang(Clinical Laboratory,the First People＇s Hospital of Fuyang District,Hangzhou,Zhefiang 311400,China)
出处
《中国卫生检验杂志》
CAS
2018年第19期2362-2365,共4页
Chinese Journal of Health Laboratory Technology
关键词
神经性厌食症
血象
骨髓象
Anorexia nervosa
Blood smear
Bone marrow smear
