摘要
目的探讨对老年轻度认知功能障碍患者使用盐酸多奈哌齐的治疗效果。方法选取该院于2016年11月—2017年10月收治的90例老年轻度认知功能障碍患者,将其随机分为对照组与观察组,每组45例。其中给予对照组患者常规治疗方式,观察组患者则在常规治疗基础上加以使用盐酸多奈哌齐治疗方式。对比两组患者经治疗后2、4、8周的认知功能及日常生活自理能力改善情况。结果观察组用药第2周开始起效,治疗后2、4、8周时MMSE评分分别为(17.48±4.14)分、(18.89±4.52)分、(19.87±4.01)分明显优于对照组患者(15.57±4.07)分、(15.11±3.99)分、(15.48±3.99)分(t=2.487,3.478,4.478;P<0.05);ADL评分于2、4、8周的分别为(36.47±7.89)分、(30.57±8.87)分、(26.47±13.77)分显著优于对照组患者(41.47±6.99)分、(40.11±9.74)分、(39.59±10.01)分(t=2.479,4.478,5.147; P<0.05)。结论老年轻度认知功能障碍患者的治疗过程中采取盐酸多奈哌齐可显著提升治疗效果,且起效迅速,对其预后生活质量的改善有着一定的意义。
Objective To study the curative effect of donepezil hydroehloride in treatment of senile patients with mild cognitive dysfunction. Methods 90 cases of senile patients with mild cognitive dysfunction admitted and treated in our hospital fi＇om November 2016 to October 2017 were selected and randomly divided into two groups with 45 cases in each, the control group used the routine treatment way, while the observation group were treated with donepezil hy- drochloride on the basis of the control group, and the cognitive functions in 2, 4, 8 weeks after treatment and improve- ment situation of daily self-care ability were compared between the two groups. Results The medication in the observa- tion group begun to take effect from the second week, and the MMSE scores at 2, 4 and 8 weeks after treatment were respectively （17.48±4.14）points,（18.89±4.52）points,（19.87±4.01）points, which were obviously better than those in the control group, [（15.57±4.07）points,（15.11±3.99）points,（15.48±3.99）points （t=2.487,3.478,4.478;P〈0.05）], and the ADL scores at 2,4,8 weeks were obviously better than those in the control group, [（36.47±7.89）,（30.57±8.87）,（26.47±13.77） vs （41.47 ±6.99）points, （40.11 ±9.74）points, （39.59 ±10.01）points, （t =2.479,4.478,5.147; P 〈0.05）]. Conclusion The donepezil hydrochloride in treatment of senile patients with mild cognitive dysfunction can improve the treatment effect with rapid onset, and it is of a certain significance to the improvement of quality of life.
作者
段庆希
DUAN Qiug-xi(Department of Neruology,Luozhuang Central Hospital,Linyi,Shandong Province,276017 China)
出处
《系统医学》
2018年第18期55-56,59,共3页
Systems Medicine
