摘要
目的探讨羟苯磺酸钙治疗脑梗死患者对神经肽、C反应蛋白(CRP)和皮质醇水平影响。方法选取2016年4月至2017年11月我院收治脑梗死患者58例随机分为常规组(常规治疗,29例)和干预组(常规治疗联合羟苯磺酸钙治疗,29例),比较两组患者疗效及治疗前后神经肽、CRP和皮质醇水平。结果常规组治疗总有效率显著低于干预组(72.41%vs.96.55%,P<0.05)。治疗前,两组患者神经肽、CRP和皮质醇水平比较无统计学意义(P>0.05);治疗14 d后,两组患者神经肽、CRP和皮质醇水平均显著下降,但干预组患者下降程度更显著(P<0.05)。结论羟苯磺酸钙治疗脑梗死可降低患者神经肽、CRP及皮质醇水平,提高患者临床疗效。
Objective To investigate the effect of calcium dobesilate on neuropeptide,C-reactive protein（CRP） and cortisol in patients with cerebral infarction.Methods Select 58 case of patients with cerebral infarction in our hospital during Apr.,2016~Nov.,2017,randomly divide them to routine group（routine treatment,29 cases） and intervention group（conventional treatment with calcium dobesilate,29 cases）,compare the two groups of patients in efficacy and neuropeptide,CRP and cortisol levels before and after treatment.Results The total effective rate of treatment in the conventional group was significantly lower than that in the intervention group（72.41% vs.96.55%,P〈0.05）.Before treatment,the levels of neuropeptide,CRP and cortisol in the two groups were not statistically significant（P〉0.05）.After 14 days of treatment,the levels of neuropeptide,CRP and cortisol decreased significantly in both groups,but the level of decrease More significant（P〈0.05）.Conclusion Calcium dobesilate in the treatment of cerebral infarction can reduce the nerve sheath,CRP and cortisol levels in patients with clinical efficacy.
作者
陈飞燕
卢翠铃
郑书恭
Chen Feiyan;Lu Cuiling;Zheng Shugong(Department of Neurology,Dalang Hospital,Dongguan 523770,China)
出处
《哈尔滨医药》
2018年第5期405-406,共2页
Harbin Medical Journal
基金
东莞市科技计划医疗卫生类科研项目(201510515000271)
关键词
脑梗死
羟苯磺酸钙
神经肽
C反应蛋白
皮质醇
Cerebral infarction；Calcium dobesilate；Neuropeptide；C-reactive protein；Cortisol
