摘要
目的:探讨肺炎支原体感染对肾病综合征儿童激素敏感频复发的影响。方法:回顾性分析2007年6月—2017年6月124例激素敏感频复发型肾病综合征合并急性呼吸道感染患儿的临床资料,将肺炎支原体(MP)感染患儿设为观察组(66例),其他感染患儿设为对照组(58例),分析所有患儿呼吸道感染的病原微生物分布,并比较患儿治疗前后的临床症状、血液生化指标、胸部X线影像学检查及临床疗效。结果:124例患者中共分离出124株病原微生物,其中肺炎支原体66株,占53. 2%,卡他莫拉菌18株,占14. 5%,EB病毒12株,占9. 7%。治疗后,两组患儿各血液生化指标均得以显著改善(P <0. 001);治疗后,观察组的24 h尿蛋白显著低于对照组,差异有统计学意义(P <0. 001)。观察组患儿完全缓解率为51. 5%,显著高于对照组的32. 8%,差异有统计学意义(P <0. 05);观察组患儿临床治疗有效率为86. 4%,与对照组治疗有效率81. 0%比较,差异无统计学意义(P> 0. 05)。结论:激素敏感频复发型肾病综合征合并急性呼吸道感染患儿在经过系统治疗后,大部分可以得以缓解,血液生化指标得以明显改善,采用阿奇霉素治疗激素敏感频复发型肾病综合征诱发的急性呼吸道感染患儿完全缓解率显著优于其他药物。
Objective ：To investigate the effect of nephrotic syndrome in children with steroid sensitive frequency of recurrence of mycoplasma pneumonia infection. Methods ： Retrospective analysis of clinical data from June 2007 to June 2017,124 cases of hormone sensitive frequently relapsing nephrotic syndrome in children with acute respiratory tract infection, mycoplasma pneumonia （MP） infection were divided into MP group （66 cases） and other infections in children as the control group （58 cases） , analysis of all children with respiratory tract infection pathogen distribution, and compare the clinical symptoms before and after treatment, blood biochemical index, examination and clinical curative effect of chest X - ray imaging. Results ： All 124 cases of patients with isolated 124 strains of pathogenic microbes,including 66 strains of Mycoplasma pneumoniae accounted for 53.2% , Mora M. 18 strains of EB virus accounted for 14.5% ;12 strains of 9.7%. After treatment,the blood biochemical indexes of two groups were significantly improved （P 〈 0.001 ） ;after treatment, MP infection group 24 hours urinary protein was significantly lower than the control group, the difference was statistically significant （ P 〈 0.001 ）. MP infection group complete remission rate was 51.5 % higher than that of the control group 32.8 % , the difference was statistically significant （P 〈 0.05 ）. MP infection group of children with clinical treatment efficiency was 86.4% and the effective rate was 81% in control group （ no statistically significant difference between P 〉 0.05 ）. Conclusion ： The hormone sensitive frequently relapsing nephrotie syndrome complicated with acute respiratorytract infection in children after treatment, most can be alleviated, blood biochemical indexes were obviously improved. The complete remission rate of children with acute respiratory infection induced by hormone sensitive nephrotie syndrome was significantly better than that of other treatments.
作者
周丽
ZHOU Li(Xuchang Municipal Hospital,Xuchang 461000,China)
出处
《临床医药实践》
2018年第11期816-819,共4页
Proceeding of Clinical Medicine
关键词
支原体
感染
肾病综合征
激素
敏感
myeoplasma
infection
nephrotie syndrome
hormone
sensitivity
