摘要
胰腺癌是恶性程度最高的消化道肿瘤之一.侵袭和转移是胰腺癌的重要生物学特性,也是导致胰腺癌预后不良的重要因素.近年来,大量研究证明多种分子、基因和蛋白参与调控胰腺癌细胞的侵袭和转移.因此,深入揭示和研究胰腺癌侵袭转移的分子机制,不仅有助于发现新的肿瘤标志物和胰腺癌早期诊断,还可以用来制定新的有效治疗策略以及判断预后.本文就影响胰腺癌侵袭和转移的分子靶点和机制的最新进展作一综述.
Pancreatic cancer is one of the most malignant tumors of the digestive system. Invasion and metastasis are important biological characteristics of pancreatic cancer and contribute greatly to the poor prognosis of the patients. Many lines of evidence have recently revealed that many molecules, genes and proteins regulate the invasion and metastasis of pancreatic cancer cells. Therefore, exploration and a deep understanding of the molecular mechanism accounting for the invasion and metastasis of pancreatic cancer can help find novel pancreatic cancer biomarkers, improve early diagnosis, develop novel and effective treatment strategies, and predict the prognosis. This review summarizes the latest progress in the research of molecular targets for pancreatic cancer and the mechanisms by which they participate in the invasion and metastasis of this aggressive malignancy.
作者
李子一
孙学英
Zi-Yi Li;Xue-Ying Sun(The Hepatosplenic Surgery Center,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China)
出处
《世界华人消化杂志》
CAS
2018年第28期1651-1659,共9页
World Chinese Journal of Digestology
基金
国家重点研发项目课题
No.2017YFC1308602
国家自然基金
No.81472321~~
关键词
胰腺癌
侵袭
转移
分子靶点
调控机制
Pancreatic cancer
Invasion
Metastasis
Molecular targets
Regulatory mechanism.
