摘要
目的检测胃腺癌中SIX1和CD147两个因子的表达,关注二者的相关性及其临床意义.方法本实验选择79例胃腺癌作为观察组,留取临床资料及术后留取的石蜡标本,选择45例正常胃黏膜的石蜡标本作为对照组,应用免疫组化二步法检测二组中SIX1和CD147的表达.结果二组中SIX1和CD147的表达差别有统计学意义,观察组中SIX1和CD147的表达与肿瘤的最大径和浸润深度密切相关, SIX1的表达与淋巴结转移密切相关,CD147的表达与分化程度密切相关,线性相关分析显示观察组中SIX1和CD147的表达具有正相关性,观察组中SIX1和CD147的表达与生存时间相关.结论 SIX1和CD147在胃腺癌组织中表达明显升高,对肿瘤的形成和发展有一定的调节作用. SIX1和CD147可能具有正向协同作用, SIX1和CD147的表达与预后相关.
AIMTo detect the expression of SIX1 and CD147 and analyzetheir clinical significance in gastric adenocarcinoma.METHODSSeventy-nine cases of gastric adenocarcinoma were collected as an observation group, and 45 normal gastricmucosal samples were collected as a control group.Expression of SIX1 and CD147 in these samples wasdetected by immunohistochemistry.RESULTSExpression of SIX1 and CD147 differed significantlybetween the two groups. Expression of SIX1 and CD147was correlated with maximum tumor diameter andtumor infiltration. Expression of SIX1 was correlatedwith lymph node metastasis, and expression of CD147was correlated with differentiation. There was a positivecorrelation between SIX1 and CD147 expression in theobservation group. The expression of SIX1 and CD147was correlated with survival time.CONCLUSION Higher expression of SIX1 and CD147 can promote tumorformation and progression in gastric adenocarcinoma.SIX1 and CD147 may have synergistic effects, and theycorrelate with prognosis in gastric adenocarcinoma.
作者
邱雷
胡奕
邓中民
Lei Qiu;Yi Hu;Zhong-Min Deng(Department of DigestiveMedicine,Huzhou First People＇s Hospital,Huzhou 313000,ZhejiangProvince,China)
出处
《世界华人消化杂志》
CAS
2018年第30期1742-1747,共6页
World Chinese Journal of Digestology
