摘要
目的探究2型糖尿病患者视网膜病变(DR)危险因素。方法选取2017年3月至2018年3月于我院住院的2型糖尿病(T2DM)患者985例,完整采集患者一般资料和生化资料。按2002年国际临床分级标准将眼底病变分期为无糖尿病视网膜病变组(NDR) 402例,非增值性糖尿病视网膜病变组(NPDR) 475例,增值性糖尿病视网膜病变组(PDR) 108例。组间正态分布且方差齐性的计量资料用单因素方差分析,非正态分布或方差不齐的计量资料用非参数检验;组间分类资料用R×C卡方检验;组间具有差异的指标纳入多分类Logistic回归分析。结果三组间年龄、病程、收缩压、空腹血糖、空腹C肽、谷草转氨酶、谷丙转氨酶、尿素氮、肌酐、总胆固醇、甘油三酯、钾离子、24h尿蛋白和FT3均存在显著性差异(P <0. 05)。Logistic回归分析:病程、收缩压、24h尿蛋白是糖尿病视网膜病变的独立危险因素(P <0. 05),非酒精性脂肪肝(NAFDL)可能是PDR的保护性因素(P <0. 05)。结论病程、收缩压、24h尿蛋白是糖尿病视网膜病变的独立危险因素。
Objective To investigate the risk factors of diabetic retinopathy（ DR） in patients with type 2 diabetes mellitus in Mudanjiang area. Methods 985 patients with type 2 diabetes mellitus（ T2 DM） admitted to our hospital from March 2017 to March2018 were enrolled. The general data and biochemical data of patients were collected. The retinal lesions were graded as non-diabetic retinopathy group（ NDR）-402 cases,non-proliferative diabetic retinopathy group（ NPDR）-475 cases,and proliferative diabetic retinopathy group（ PDR）-108 cases,according to the 2002 international clinical grading criteria. The data which was a normal distribution and homogeneity of variance between groups were analyzed with one-way ANOVA,non-normal distributions or uneven variance data were tested with non-parametric tests; classification data were tested with R × C chi-square test; indicators with differences between groups were included in multi-category Logistic regression analysis. Results There was significant difference in age,course of disease,systolic blood pressure,fasting blood glucose,fasting C-peptide,aspartate aminotransferase,alanine aminotransferase,urea nitrogen,creatinine,total cholesterol,triglyceride,potassium,24-hour urinary protein and FT3 among the three groups（ P 〈 0. 05）. Logistic regression analysis showed that duration of disease,systolic blood pressure,24-hour urinary protein were independent risk factors for diabetic retinopathy,and non-alcoholic fatty liver disease（ NAFLD） may be a protective factor for PDR（ P 〈 0. 05）. Conclusion The course of disease,systolic blood pressure and 24-hour urinary protein are independent risk factors for diabetic retinopathy.
作者
简怀平
王毅祯
周桂敏
于艳梅
JIAN Huai-ping(Department of Endocrinology,Diabetes Branch,Mudanjiang Cardiovascular Hospital,Mudanjiang 157011,China)
出处
《牡丹江医学院学报》
2018年第5期10-14,共5页
Journal of Mudanjiang Medical University
关键词
糖尿病视网膜病变
危险因素
病程
24h尿蛋白
收缩压
diabetic retinopathy
risk factors
course of disease
24-hour urine protein
systolic blood pressure
