摘要
目的了解广东地区汉族人群乙醛脱氢酶2基因(ALDH2)Glu504Lys的多态性分布。方法应用DNA微阵列芯片法对296例广东地区汉族人群中的ALDH2基因进行多态性分析。结果男性组ALDH2*1/*1、ALDH2*1/*2、ALDH2*2/*2 3种基因型频率分别为53.1%、39.6%、7.3%,女性组分别为57.7%、33.7%、8.6%,2组间差异无统计学意义(P>0.05);男性组ALDH2*1和ALDH2*2等位基因频率分别为72.9%、27.1%,女性组分别为74.5%、25.5%,2组间差异无统计学意义(P>0.05)。广东地区汉族人群3种基因型的频率分别为54.7%、37.5%、7.8%,突变型基因频率达45.3%;广东地区汉族人群ALDH2*1和ALDH2*2等位基因频率分别为73.5%、26.5%。结论广东地区汉族人ALDH2基因多态性在性别中无差异,ALDH2*2等位基因频率高于山东、上海等地区。
Objective To investigate aldehyde dehydrogenase 2 gene（ALDH2）Glu504 Lys polymorphism among the Han population in Guangdong.Methods ALDH2 gene polymorphisms of 296 samples were analyzed by DNA microarray method.Results A total of tree genotypes of ALDH2 were detected including ALDH2＊1/＊1,ALDH2＊1/＊2 and ALDH2＊2/＊2,frequencies of the three genotypes were 53.1%,39.6%,7.3%respectively in male group,frequencies of the three genotypes were 57.7%,33.7%,8.6% respectively in female group,there were no significant differences between different genders（P0.05）.The allele frequency of ALDH2＊1 and ALDH2＊2 were 72.9%and 27.1%in male group,the allele frequency of ALDH2＊1 and ALDH2＊2 were 74.5%and 25.5%in female group,significant difference was not found in allele frequency of ALDH2 between the two groups（P0.05）.The frequencies of ALDH2 genotypes among the Han population in Guangdong were ALDH2＊1/＊1（54.7%）,ALDH2＊1/＊2（37.5%）and ALDH2＊2/＊2（7.8%）respectively,the mutant gene frequency was 45.3%.The allele frequency of ALDH2＊1 and ALDH2＊2 were 73.5%and 26.5%in Han population of Guangdong province.Conclusion Gene polymorphism of aldehyde dehydrogenase 2 had no correlation with gender,and the allele frequency of ALDH2＊2 in Guangdong population was higher than that in Shandong,Shanghai and other areas.
作者
王慧
罗娥
欧雅文
WANG Hui;LUO E;OU Yawel,(Department of Clinical Laboratory,the First Affiliated Hospital of Guangzhou Medical College,Guangzhou,Guangdong 510120,China;Guangzhou Medical College,Guangzhou,Guangdong 510180,China)
出处
《检验医学与临床》
CAS
2018年第21期3197-3199,3202,共4页
Laboratory Medicine and Clinic
