摘要
目的:探讨托毒生肌散联合新型敷料治疗慢性难愈创面效果及对渗出液中TGF-β1、IL-1β的影响。方法:选取在医院伤口愈合中心治疗难愈性创面患者60例,随机分为观察组30例和对照组30例。对照组按时用新型敷料换药,观察组用托毒生肌散联合新型敷料外敷。疗程4周。分别在治疗前、治疗后1周、2周、3周、4周时检测创面渗出液中TGF-β1及IL-1β水平。结果:2组治疗2周、3周、4周时患者创面面积差异均有统计学意义(P<0.05);对照组治疗4周时创面面积与治疗前比较,差异有统计学意义(P<0.05);观察组治疗2周、3周、4周时创面面积与治疗前比较,差异有统计学意义(P<0.05);2组治疗前渗出液中IL-1β、TGF-β1水平差异无统计学意义(P>0.05);治疗1周(TGF-β1除外)、2周、3周、4周时患者渗出液中IL-1β、TGF-β1水平差异均有统计学意义(P<0.05);2组治疗4周时渗出液中IL-1β、TGF-β1水平与治疗前比较,差异有统计学意义(P<0.05)。结论:对于慢性难愈创面,使用托毒生肌散联合湿性敷料外敷,能逐渐上调TGF-β1、下调IL-1β,促进创面愈合,效果优于独用湿性敷料。
Objective： To investigate the effect of Tuodu Shengji powder combined with new dressing on chronic re- fractory wound and its effect on TGF-β1 and IL-1β in exudate. Methods： 60 patients with chronic refractory wounds were randomly divided into observation group of 30 cases and 30 cases in the control group. The control group was treated with new dressing on time, the observation group was treated with Tuodu Shengji powder applied externally at the same time with the new dressing. The course of treatment was 4 weeks. The levels of TGF-β1, IL-1β in wound exudate were measured before treatment, at 1 weeks, 2 weeks, 3 weeks, and 4 weeks, respectively. Results： The two groups were treated for 2 weeks, 3 weeks, 4 weeks in patients with wound area showed significant differences （ P〈0.05 ）; The wound area in the control group was compared with that before treatment for 4 weeks, the difference was statistical- ly significant （ P〈0.05 ） ; The wound area in the observation group was compared with that before treatment at 2weeks, 3 weeks and 4 weeks after treatment, the difference was statistically significant （ P〈0.05 ） ; there was no significant difference in the levels of IL-1β, TGF-β1 between the two groups before treatment （ P〉0.05 ） ; at 1 weeks （ except TGF-β1 ）, 2, 3, 4 weeks the levels of IL-1β, and TGF- β1 in the exudate were statisiieally significant （ P〈0.05 ） ; the two groups after 4 weeks of treatment of IL-1β, level TGF-β1 in exudate compared with before treatment, the difference was statistically significant （ P〈0.05 ）. Conclusion： The chronic refractory wounds were treated with Tuodu Shengji powder combined with wet dressing, it can gradually increase TGF-β1 and down regulate IL-1β, promote wound healing, the effect is better than the sole wet dressing.
作者
张坤
任琳
彭金霞
ZHANG Kun;REN Lin;PENG Jinxia(Xinxiang Central Hospital,Henan Xinxiang 453000,China;People＇s Hospital Affiliated of Hubei Medical College,Hubei Shiyan 442000,China)
出处
《中医药临床杂志》
2018年第9期1684-1687,共4页
Clinical Journal of Traditional Chinese Medicine
基金
湖北省科技攻关项目(NO:EK2013D150053001209)
