摘要
目的观察双歧杆菌乳杆菌三联活菌片联合拉克替醇散治疗肝硬化自发性细菌性腹膜炎的临床疗效。方法将180例肝硬化合并自发性细菌性腹膜炎患者随机分为对照组及试验组,每组各90例。对照组给予抗生素治疗,试验组在对照组的基础上给予双歧杆菌乳杆菌三联活菌片5 mg·d^(-1),拉克替醇散1g·d^(-1),口服,连续给药2周。观察2组患者的临床疗效、临床表征和肝功能恢复情况。结果治疗后,对照组和试验组的总有效率分别为44.44%(40例/90例)和67.78%(61例/90例),差异有统计学意义(P<0.05)。治疗后,对照组和试验组的腹痛消失时间分别为(9.03±0.56)和(7.23±0.28)h,腹泻停止时间分别为(4.96±0.18)和(2.56±0.26)d,腹部压痛消失分别为(11.21±0.55)和(8.39±0.25)min,体温恢复正常时间分别为(7.54±0.25)和(5.36±0.52)h,腹水培养阴性开始时间分别为(9.36±0.60)和(7.69±0.36)d,差异均有统计学意义(均P<0.05)。治疗后,2组的谷丙转氨酶(ALT)、总胆红素(TBIL)和白蛋白(Alb)与治疗前相比,差异均有统计学意义(均P<0.05);试验组与对照组相比,差异均有统计学意义(均P<0.05)。试验组出现恶心1例,对照组出现恶心2例,胃胀2例,试验组和对照组的药物不良反应分别为1.11%(1例/90例)和4.44%(4例/90例),差异无统计学意义(P>0.05)。结论双歧杆菌乳杆菌三联活菌片联合拉克替醇散治疗肝硬化自发性细菌性腹膜炎患者临床疗效较好,可显著改善患者预后。
Objective To analyze the clinical effect of live combined bifidobacterium and lactobacillus tablets and lactitol powder in the treat- ment of spontaneous bacterial peritonitis of liver cirrhosis. Methods A total of 180 patients with cirrhosis and spontaneous bacterial peritonitis were randomly divided into control group and treatment group, 90 cases in each group. Control group was given routine antibiotic treatment. Treatment group were given live combined bifidobacterium and lactobacil- lus tablets 5 mg·d-1, laetitol powder 1 g · d-1 on the basis of control group. All patients were treated for 2 weeks. After treatment, the clinical efficacy, clinical characterization and recovery of liver function in two groups were observed. Results The total efficacy in control group and treatment group were 44. 44% （40 cases/90 cases） and 67. 78% （61 cases/90 cases）, with significant difference （ P 〈 0. 05 ）. The disappearance time of abdominal pain in control group and treatment group were （ 9.03 ＋ 0. 56 ） and （ 7.23±0. 28 ） h, the durations of diarrhea cessation were （4. 96±0. 18） and （2. 56±0. 26） d, the disappearance time of abdominal tenderness were （ 11.21±0. 55） and （8.39±0. 25 ） min, the time of body temperature return to normal were （7.54± 0.25 ） cultures negative start time were （9.36±0. 60）and （7.69±0. 36） d, all with significan （5.36±O. 52 ） h, the ascites t differences （ all P 〈 O. 05 ） ： After treatment, the levels of alanine aminotransferase （ALT）, total bilirubin （TBIL） and albumin （Alb） in two groups had significant differences compared with before treatment; and there were significant differences between control groupand treatment group （all P 〈0.105）, There was 1 case of nausea in treatment group, and there were 2 cases of nausea and 2 cases of bloating in control group. The incidence of adverse drug reactions in treatment group and control group were 1.11% （ 1 case/90 cases ）, 4. 44% （ 4 cases/90 cases ）,
作者
张瑜
田笑笑
胡新俊
ZHANG Yu;TIAN Xiao-Xiaola;HU Xin-junlb(a Department of Gastroenterology;h Department of Infectious Diseases,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,Henan Province,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2018年第19期2259-2261,2265,共4页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金资助项目(81600512)
