摘要
目的探讨润燥止痒胶囊联合他扎罗汀乳膏治疗寻常型痤疮的临床疗效。方法选取2017年3月—2018年3月在海南省皮肤病医院进行诊治的84例寻常型痤疮患者为研究对象,根据用药的差别将所有患者分为对照组和治疗组,每组各42例。对照组将面部清洁干燥后,取2 mg/cm2他扎罗汀乳膏均匀涂于患处,每晚用药一次;治疗组在对照组基础上口服润燥止痒胶囊,2 g/次,3次/d。两组患者均治疗8周。观察两组患者临床疗效,比较治疗前后两组患者的相关评分及炎症指标。结果治疗后,对照组和治疗组临床总有效率分别为80.95%、97.62%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者红斑、色素沉着、银屑病皮损面积和严重程度指数(PASI)、皮肤病生活质量指数(DLQI)评分显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后治疗组患者上述评分显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清肿瘤坏死因子(TNF-α)、白细胞介素-4(IL-4)、白细胞介素-17(IL-17)、可溶性白细胞介素-2受体(SIL-2R)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后治疗组炎症指标水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论润燥止痒胶囊联合他扎罗汀乳膏治疗寻常型痤疮可有效促进皮肤红斑及色素沉着消退,提高生活质量,改善机体炎症反应,具有一定的临床推广应用价值。
Objective To investigate the clinical curative effect of Runzao Zhiyang Capsules combined with Tazarotene Cream in treatment of acne vulgaris. Methods Patients（84 cases） with acne vulgaris in Hainan Provincial Hospital of Skin Disease from March 2017 to March 2018 were divided into control（42 cases） and treatment（42 cases） groups according to the difference of treatment. Patients in the control group were coated with Tazarotene Cream on the wound evenly, after the face was cleaned and dried, 2 mg/cm2 each time, once at night. Patients in the treatment group were po administered with Runzao Zhiyang Capsules on the basis of the control group, 2 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, the related scores and the inflammatory markers in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group were 80.95% and 97.62%, and there were differences between two groups（P 〈 0.05）. After treatment, the erythema, pigmentation, PASI, and DLQI scores in the treatment group were significantly decreased, and the difference was statistically significant in the same group（P 〈 0.05）. And the scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P 〈 0.05）. After treatment, the TNF-α, IL-4, IL-17, SIL-2 R levels in the treatment group were significantly decreased, and the difference was statistically significant in the same group（P 〈 0.05）. And the inflammatory markers levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P 〈 0.05）. Conclusion Runzao Zhiyang Capsules combined with Tazarotene Cream in treatment of acne vulgaris can effectively promote the skin erythema and pigmentation fading, also can improve the quality of life and the inflammatory response, which has a certain cli
作者
陈凯
陆捷洁
CHEN Kai;LU Jie-jie(Department of Dermatology,Hainan Provincial Hospital of Skin Disease,Haikou 255300,China)
出处
《现代药物与临床》
CAS
2018年第9期2382-2385,共4页
Drugs & Clinic
