摘要
目的:探讨妊娠期高血压患者血清可溶性凝集素样氧化型低密度脂蛋白受体-1(sLOX-1)与人绒毛膜促性腺激素(β-hCG)及妊娠结局的相关性。方法:收集本院收治的妊娠期高血压患者68例(观察组),选取同期正常产检的健康孕妇68例(对照组),采用酶联免疫吸附法(ELISA)检测sLOX-1浓度,化学发光分析法检测血清β-hCG水平,比较并分析sLOX-1、β-hCG水平与不良妊娠结局的关系。结果:观察组血清sLOX-1、β-hCG水平高于对照组,且观察组中重度>中度>轻度(均P<0.05);Pearson相关性分析显示,观察组血清sLOX-1与β-hCG水平呈明显正相关(r=0.742,P=0.000);观察组血清sLOX-1水平与妊娠高血压疾病、早产、胎儿窘迫、胎膜早破、胎儿生长受限呈正相关,β-hCG水平与妊娠期高血压疾病、胎儿窘迫、胎儿生长受限呈正相关(均P<0.05),与早产、胎膜早破无明显相关性(P>0.05)。结论:妊娠期高血压孕妇血清sLOX-1、β-hCG水平升高,并与不良妊娠结局相关,临床中可通过血清sLOX-1、β-hCG水平检测辅助预测不良妊娠结局发生。
Objective： To investigate the correlation between serum soluble lectin like oxidized low density lipoprotein receptor 1 （sLOX 1） or human chorionic gonadotropin （β hCG） and pregnancy outcomes of pregnant women with pregnant induced hypertension. Methods： 68 pregnant women with pregnant induced hypertension in Jurong people＇s hospital of Jiangsu province were selected into observation group. During the same period, another 68 healthy pregnant women who had received normal prenatal examination were selected into control group. Enzyme linked immunosorbent assay （ELISA） was used for measuring serum sLOX 1 concentration , chemiluminescence assay was used to detect serum β hCG levels of all included pregnant women. And the level of serum sLOX 1 or β hCG related to adverse outcomes of pregnant women were compared between the two groups. Results： The levels of serum sLOX 1and β hCG pregnant women in observation group were significant higher than those of pregnant women in control group （ P 〈 0.05 ）. The levels of serum sLOX 1 and β hCG of pregnant women with severe pregnancy induced hypertension were significant higher than those of pregnant women with moderate pregnancy induced hypertension, and those of pregnant women with moderate pregnancy induced hypertension were significant higher than those of pregnant women with mild pregnancy induced hypertension （ P 〈0.05）. The pearson correlation analysis had showed that there was a positive correlation between levels of serum sLOX 1 and β hCG with pregnancy induced hypertension （ r=0.742, P =0.000）. The level of serum sLOX 1 of pregnant women in observation group was positively correlated with pregnancy induced hypertension, premature delivery, fetal distress, premature rupture of membranes, and fetal growth restriction （ P 〈0.05）. The level ofβ hCG of pregnant women in observation group was positive correlated with pregnancy induced hypertension, fetal distress and fetal growth restriction （ P 〈0.05）, but was not correl
作者
周娟
韩克
ZHOU Juan;HAN Ke(Jurong People＇s Hospital of Jiangsu Province,Jiangsu Province,212400;Nanjing Gulou Hospital)
出处
《中国计划生育学杂志》
2018年第10期961-964,共4页
Chinese Journal of Family Planning
