摘要
目的探讨神经生长因子对新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)患儿神经行为及生物标志物的影响。方法选择84例HIE患儿作为研究对象,随机分为试验组(42例)和对照组(42例),两组患儿均给予常规对症和支持治疗,试验组患儿在此基础上给予鼠神经生长因子治疗,两组患儿均连续治疗14d。观察两组患儿治疗效果、新生儿神经行为评定(neonatal behavioral neurological assessment,NBNA)、血清髓鞘碱性蛋白(myelin basic protein,MBP)、神经元特异性烯醇化酶(neuron specific enolase,NSE)水平以及智力发育指数(MDI)和精神运动发育指数(PDI)。结果试验组患儿治疗总有效率(37例,88.10%)高于对照组(29例,69.05%),差异有统计学意义(P<0.05);试验组患儿治疗7d和14d的NBNA评分为(34.35±5.27)分和(37.80±3.08)分,均高于对照组,差异有统计学意义(P<0.05);试验组患儿治疗后7d血清MBP和NSE水平为(10.57±2.57)分和(26.60±6.42)分,治疗后14d为(7.73±1.89)分和(17.46±3.60)分,上述指标水平均低于对照组,差异有统计学意义(P<0.05);试验组患儿出生3、6、9个月时MDI和PDI得分均高于对照组,差异有统计学意义(P<0.05)。结论神经生长因子可促进新生儿缺氧缺血后脑组织损伤的修复,改善患儿的神经行为功能以及后期智力和运动发育,治疗效果显著。
Objective To explore the effect of nerve growth factor on neurobehavioral function and biomarkers in neonatal hypoxic-ischemic encephalopathy （HIE）. Methods A total of 84 HIE cases were selected and divided randomly into the observation group and control group, and each group consisted of 42 cases. The patients of both groups were treated with the conventional symptomatic and supportive treatment and the patients of the observation group were treated additionally with rat nerve growth factor. The course of treatment was 14 days. The therapeutic effect, neonatal behavioral neurological assessment （NBNA）, levels of serum myelin basic protein （MBP） and neuron specific enolase （NSE）, mental development index （MDI） and psychomotor development index （PDI） in both groups were observed. Results The total therapeutic effective rate in the observation group （88.10% with 37 cases） was significantly higher than those in the control group （69.05% with 29 cases） （ P 〈0.05）. The NBNA scores after 7-day and 14-day treatment in the observation group were （34.35±5.27） and （37.80±3.08） respectively, and they were significantly higher than that in the control group （ P 〈0.05）. The levels of serum MBP and NSE after 7-day treatment were （10.57±2.57） and （26.60±6.42） respectively and those after 14-day treatment were （7.73±1.89） and （17.46±3.60） in the observation group, and those indexes were significantly lower than those in the control group （ P 〈0.05）. The scores of MDI and PDI at 3, 6 and 9 months were significantly higher in the observation group than in the control group （ P 〈0.05）. Conclusion Nerve growth factor can promote the repair of brain tissues and improve the neurobehavioral function and the late development of intelligence and motor with remarkable therapeutic effect in neonatal HIE.
作者
王进
于凤琴
Wang Jin;Yu Fengqin(Neonatal Intensive Care Unit,Women ＆ Infants Hospital of Zhengzhou.Zhengzhou 450000,China)
出处
《成都医学院学报》
CAS
2018年第5期621-623,645,共4页
Journal of Chengdu Medical College
