摘要
目的探究玻璃体腔注射康柏西普联合激光光凝对糖尿病视网膜病变(DR)患者症状改善及血清碱性成纤维细胞生长因子(bFGF)、胰岛素样生长因子1(IGF-1)、血管内皮生长因子(VEGF)水平变化的影响。方法选取2014年12月至2017年5月我院DR患者62例,依据治疗方案不同分组,各31例。对照组施行激光光凝治疗,研究组予以玻璃体腔注射康柏西普+激光光凝治疗。治疗后3个月,统计2组症状改善时间及并发症发生情况,并对比治疗前后视网膜厚度、最佳矫正视力及血清bFGF、IGF-1、VEGF水平变化情况。结果相较于对照组,研究组视网膜水肿改善、眼底出血及渗出吸收时间均较短,差异有统计学意义(P<0.05);研究组治疗后视网膜厚度较低,最佳矫正视力较高,差异有统计学意义(P<0.05);2组并发症发生率对比,研究组6%(2/31)低于对照组39%(12/31),差异有统计学意义(P<0.05);研究组治疗后血清bFGF、IGF-1、VEGF水平均较低,差异有统计学意义(P<0.05)。结论联合采用激光光凝、玻璃体腔注射康柏西普治疗DR,可有效促进视网膜厚度恢复,提高最大矫正视力,明显缩短患者症状改善时间,显著降低并发症发生率及血清bFGF、IGF-1、VEGF水平。
Objective To investigate the effect of intravitreal injection of Conbercept and laser photocoagulation on the symptom improvements and changes of serum basic fibroblast growth factor（bFGF）, insulin-like growth factor 1（IGF-1） and vascular endothelial growth factor（VEGF） levels in patients with diabetic retinopathy（DR）.Methods Sixty-two patients with DR admitted in our hospital between December 2014 and May 2017 were included in the study, and divided into 2 groups according to different treatment protocols（n=31 each）. The control group was treated with laser photocoagulation, and the study group was treated with intravitreal injection of conbercept ＋ laser photocoagulation. At 3 months after the treatment, the time of symptom improvements and the occurrence of compli-cations were recorded. The retinal thickness, best corrected visual acuity and changes of serum bFGF, IGF-1, VEGF levels before and after the treatment were compared. Results Compared with the control group,the time of retinal edema improvement,fundus hemorrhage and exudate absorption in the study group were shorter, with statistically significant differences（P〈0.05）. The retinal thickness was lower and the best corrected visual acuity was higher in the study group after the treatment, with statistically significant difference（P〈0.05）.The incidence of complications in the study groupwas lower than that in the control group [6%（2/31） vs 39%（12/31）（P〈0.05）], with statistically significant difference（P〈0.05）. The serum bFGF, IGF-1, and VEGF levels in the study group were lower after the treatment, with statistically significant difference（P〈0.05）.Conclusion Laser photocoagulation and intravitreal injection of conbercept in the treatment of DR may effectively promote the recovery of retinal thickness, increase the maximum corrected visual acuity, shorten the time of symptom improvements, and significantly reduce the incidence of complications and serum bFGF, IGF-1 and VEGF levels.
作者
张石华
戴莉
李晓雯
Zhang Shihua,Dai Li,Li Xiaowen(Department of Ophthalmology, Yuncheng Municipal Central Hospital, Shanxi 044000, China)
出处
《中国药物与临床》
CAS
2018年第10期1667-1670,共4页
Chinese Remedies & Clinics
基金
国家自然科学基金(面上项目)(81170144)
