摘要
自噬是广泛存在于真核细胞中的生命现象,维持细胞内的稳态及胞内成分的不断更新,在保持细胞正常的生理状态过程中起着至关重要的调节作用。其是一条依赖溶酶体降解的途径,它具有清除细胞内蛋白质聚集体、损伤的细胞器,维持细胞内稳态的作用,同时还参与细胞很多生理和病理过程,尤其与肿瘤和神经退行性疾病的发生发展密切相关。近年来,中药单体通过调控自噬的某些信号通路,影响和抑制肿瘤的发生发展的作用机制日渐明了;此外,中医药在防治老年神经退行性疾病理论知识方面也取得了很多突破;本文介绍了与自噬密切相关的信号通路如雷帕霉素靶向蛋白信号通路（m TOR）,磷脂酰肌醇-3-激酶/蛋白激酶B（PI3K/Akt）信号转导通路,活性氧（ROS）信号通路,核转录因子-κB（NF-κB）信号通路,另外还从中药单体调节自噬机制方面,概述中药单体在肿瘤和神经退行性疾病治疗中的应用及其分子机制。诸多研究表明,中药单体通过激活自噬途径,调节自噬活性,在肿瘤治疗和防治老年病如帕金森、阿尔兹海默症、亨廷顿等疾病方面有很好的改善作用,研究中药单体对肿瘤和神经退行性疾病的防治是崭新的思路和方法,以期为中医药研究工作者在探索中医药调控自噬的作用靶点研究中提供基础理论支撑,发现更多的中药及单体化合物通过调节自噬用于治疗肿瘤、神经退行性疾病等多种疾病。
Autophagy is a widespread phenomenon in eukaryotic cells,with the aim to maintain the intracellular homeostasis and the constant update of intracellular components,and play a crucial regulatory role in maintaining the normal physiological state of cells. It is a way to degradate by relying on lysosomal,has organelles for clearing intracellular protein aggregates and damages,and maintains intracellular homeostasis. At the same time,it is also involved in many physiological and pathological processes of cells,especially closely related to the occurrence and development of tumors and neurodegenerative diseases. In recent years, traditional Chinese medicine（ TCM） monomers have been found to have mechanisms for impacting and inhibiting the occurrence and development of tumor through the regulation of some signaling pathways of autophagy; In addition,TCM has many breakthroughs in the theoretical knowledge of prevention and treatment of neurodegenerative diseases. This article describes the signal pathways closely related to autophagy,such as rapamycin-targeted protein signaling（ m TOR）,phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway（ PI3 K/Akt）,reactive oxygen species signaling（ ROS） and nuclear factor（ NF）-κB. In addition,it also summarizes the effect of TCM monomers in the treatment of tumor and neurodegenerative diseases by regulating autophagy mechanism and its molecular mechanism of action. Many studies have shown that TCM monomers can improve autophagy via autophagy pathway and play an important role in treatment and prevention of tumor and diseases,such as Parkinson＇s disease,Alzheimer＇s disease and Huntington disease. The study of the effect of TCM monomers in the prevention and treatment of cancer and neurodegenerative diseases provides new ideas and methods,in the expectation of providing basic theoretical support for TCM medicine research workers in exploring the role of TCM in the regulation of autophagy,and find more TCM and its monomeric compounds throug
作者
李欢
苗明三
LI Huan;MIAO Ming-san(College of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2018年第20期200-207,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家“十一五”科技支撑计划项目(2008BAI53B09)
河南省中原学者项目(162101510003)
国家国际合作基地项目(国科外函(2016)65号)
关键词
自噬
中药单体
自噬信号通路
肿瘤治疗
神经退行性疾病
autophagy
traditional Chinese medicine monomer
autophagy signal pathway
cancer treatment
neurodegenerative disease
