摘要
目的探讨血浆D-二聚体和凝血因子(F)水平测定在早期深静脉血栓诊断中的价值。方法纳入门诊初诊疑似深静脉血栓(DVT)症状的患者共116例,根据影像学确诊资料,分为DVT组(50例)和非DVT组(66例)。将20例年龄和性别匹配的体检健康者纳入对照组。检测各组血浆D-二聚体及凝血因子水平。结果 DVT组D-二聚体和更低的F水平高于非DVT组和对照组,差异均有统计学意义(P<0.01)。分别以66.6%和0.5μg/mL作为F和D-二聚体的诊断阈值,二者单独及联合应用的阳性预测值分别为92.9%、72.5%和100.0%。F、D-二聚体联合检测对DVT的敏感度为78.0%,特异度为100.0%。结论联合检测F抗原水平与D-二聚体在早期诊断中具有较高的诊断价值。
Objective To evaluate the value of plasma D dimer and coagulation factor ⅩⅢ （FⅩⅢ） in diagno sing deep venous thrombosis （DVT） in early times. Methods According to imaging diagnosis,a total of 116 outpatients with suspected deep vein thrombosis （DVT） were divided into DVT group （50 cases） and non DVT group （66 cases）. A total of 20 age matched healthy human were included in the control group. Detecting the level of plasma D dimer and FⅩⅢ in each group. Results Compared with the non DVT group and the con trol group,DVT group had a higher D dimer level and lower FⅩⅢ levels,the differences were statistically sig nificant （P〈0. 01）. At the thresholds of 66.6% for FRIll and 0.5 〉g/mL for D dimer,the positive predictive value of FⅩⅢ ,D dimer and combination of them for DVT were 92. 9%,72. 5% and 100.0%,respectively. The sensitivity and specificity of combined D dimer and FⅩⅢ for DVT were 78.0% and 100.0% ,respectively. Conclusion The combined detection of FⅩⅢ antigen and D dimer has confirmatory value in the diagnosis of early deep venous thrombosis.
作者
雷泽恺
祝莹
唐宁
LEI Zekai;ZHU TYing;TANG Ning(Department of Clinical Laboratory,Tongji Hospital Affiliated to Tongji Medical School,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China;Wuhan Social Welfare Institute/Wuhan Jimin Geriatric Hospital,Wuhan,Hubei 430030,China)
出处
《国际检验医学杂志》
CAS
2018年第20期2525-2527,共3页
International Journal of Laboratory Medicine
