摘要
选择东莨菪碱含量83%的洋金花提取物为原料,通过加酸成盐和冷冻结晶的方法,制得纯度为99.40%、临床用药的氢溴酸东莨菪碱,并采用DSC、自动旋光仪对样品进行了确证。结果表明,制得的氢溴酸东莨菪碱符合药典中对氢溴酸东莨菪碱的熔点和旋光度的规定。
With the flos daturae extract as the raw material （scopolamine purity of 83%） , the preparation of scopolamine hydrobromide was achieved by addition of hydrobromie acid to salt and freezing crystallization. The purity of scopolamine hydro bromide crystals was determined to be 99.40% by high periormanee liquid ehromatograpgy. Meanwhile, the crystals were confirmed by using difterential scanning calorimeter and automatic polarimeter. The resuhs revealed that the prapared scopolamine hydrobromide crystals comply with the pharmacopoeia specification for melting points and optical rotations of scopolamine hydrobromide.
作者
陈朋朋
吴泽宇
许坤
惠爱玲
张文成
CHEN Pengpeng;WU Zeyu;XU Kun;HUI Ailing;ZHANG Wencheng(Engineering Research Center of Bio-process from Ministry of Education,College of Food Science and Engineering,Hefei University of Technology,Hefei,Anhui 230009,China;Anhui Dexinjia Biological Medicine Co.,Ltd.,Fuyang,Anhui 236000,China)
出处
《农产品加工》
2018年第10期13-15,共3页
Farm Products Processing
基金
安徽省科技重大专项项目<天然东莨菪碱医药中间体的制备及产业化关键技术研究>(16030801111)
关键词
氢溴酸东莨菪碱
冷冻结晶
确证
scopolamine hydrobromide
freezing crystallization
confirmation
