摘要
近年来,国内外对针灸治疗糖尿病做了一些机制研究。本文整理和分析了Pubmed及SCI数据库中相关文献,表明针灸治疗糖尿病可能是通过多个机制起作用,包括增强胰岛功能、减轻体质量及减少食物摄入、直接降低血糖、调整体内激素等机制。此外,针灸与降糖药物还有协同增效的作用,可取得更好的治疗效果,值得进一步研究。
Acupuncture has been used to treat diabetes mellitus （DM） for more than one thousand years. In the paper, we review new progress of researches on the underlying mechanism of acupuncture intervention for DM. Results present showed that acupuncture intervention can relieve DM by 1） reducing body weight through up-regulating leptin level, suppressing insulin resistance and appetite to reduce food intake possibly by way of down-regulating expression of neuropeptide Y in the hypothala- mus, retarding gastric emptying velocity, increasing small intestinal peristalsis, raising plasma levels of glucagon-like peptide-1 （GLP-1） and peptide YY, etc. ; 2） improving pancreas function, raising insulin sensitivity to improve insulin resistance possibly by activating AMP-activated protein kinase and sirtuin 1/ peroxisome proliferator-activated receptor γ coactivator 1 α signaling, up-regulating activities of cholinergic nerve activity and nitric oxide synthase, and inhibiting apoptosis of pancreatic beta-cells; 3） lowering blood glucose possibly by increasing anaerobic glucose metabolism, regulating activities of vagal and sympathetic nerves; 4） adjusting the levels of related hormones such as melatonin, insulin, glucocorticold, epinephrine, etc. Moreover, acu- puncture treatment combined with hypoglycemic drugs has a synergic effect in lowering blood glucose, suggesting a potentially effective approach for improving DM and being worthy of further studying in clinical practice.
作者
陈超
王宏才
翟煦
黄凤
吴冬
荣培晶
CHEN Chao;WANG Hong-cai;ZHAI Xu;HUANG Feng;WU nong;RONG Pei-jing(Institute of Acupuncture moxibustion;Graduate School,China Academy of Chinese Medical Sciences,Beijing 100700,China;Acupuncture and MoXibustion Department,Beijing Hospital of Traditional Chinese Medicine,Beijing 100010;Acupuncture and MoXibustion Department,Beijing Tongren Hosptial,Beijing 100730)
出处
《针刺研究》
CAS
CSCD
北大核心
2018年第9期601-605,共5页
Acupuncture Research
关键词
针灸
糖尿病
作用机制
研究进展
Acupuncture therapy
Diabetes mellitus
Mechanism
Research progress
