摘要
目的研究氧化再生纤维素止血产品的体外降解。方法采用傅立叶红外光谱仪、电子扫描显微镜观察氧化再生纤维素止血产品降解前后的形态;分别采用凝胶色谱法和液相色谱与蒸发光散射检测器联用方法测定其降解产物。结果速即纱在降解初形态发生巨大变化;GPC确定其降解终点为10 d;确定其降解产物中含有葡萄糖(0.13%)与纤维二糖(0.17%)等成分;结论建立了GPC确定降解终点的方法,为降解终点的研究提供了新的思路和借鉴。
Objective To study the in vitro degradation of oxidized regenerated cellulose absorbable hemostatic products. Methods The morphology of the oxidized regenerated cellulose hemostatic products before and after degradation was observed by FTIR and SEM. The degradation products were determined by GPC and HILIC-ELSD. Results In the initial stage of degradation, there was a great change in morphology. GPC determined its degradation end point was 10 d; it was determined that its degradation products contained glucose （0.13%） and cellobiose （0.17%） and other components. Conclusion A method was established for determining the end point of degradation of oxidized regenerated cellulose, which provided a new idea and reference for the study of the degradation end point.
作者
陈海波
方丽
喻炎
马凤森
CHEN Haibo;FANG Li;YU Yan;MA Fengsen(Zhejiang Institute of Medical Device Testing,Hangzhou,310018;Biologics and Biomaterials Laboratory,College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou,310014)
出处
《中国医疗器械杂志》
2018年第5期380-383,共4页
Chinese Journal of Medical Instrumentation
基金
浙江省科技项目(2016F50078)
关键词
氧化再生纤维素
体外降解
可吸收
降解产物
oxidized regenerated cellulose
in vitro degradation
absorbable
degradation product
