摘要
目的探究盐酸氨溴索治疗老年呼吸机相关性肺炎(ventilator-associated pneumonia,VAP)的临床治疗效果,为临床工作提供借鉴和指导。方法选取2016-05至2018-05在吉林省人民医院重症医学科机械通气治疗过程中并发VAP的120位老年患者为研究对象,根据随机数字表法将其分为对照组与观察组。两组患者均常规给予抗感染药物治疗并进行个性化的对症治疗,其中对照组在此基础上给予糜蛋白酶雾化吸入治疗,观察组除雾化吸入糜蛋白酶外静脉注射盐酸氨溴索,观察记录两组患者的治疗效果。结果观察组患者的通气时间、支气管镜吸痰次数、痰液中白细胞数目均显著低于对照组,差异具有统计学意义(t=11.667,P<0.001;t=17.157,P<0.001;t=8.018,P<0.001);观察组患者的治疗总有效率为88.33%,高于对照组患者(76.67%),差异具有统计学意义(Z=3.020,P=0.003)。结论在治疗老年VAP方面,盐酸氨溴索具有较好的临床治疗效果,具有在临床上推广应用的价值。
Objective The objective of this study was to explore the efficacy of ambroxol hydrochloride in the treatment of elderly patients with ventilator-associated pneumonia. Methods 120 elderly patients with ventilator-associated pneumonia developed during mechanical ventilation in the department of intensive medicine, Jilin People＇s Hospital from 2016 to 2018 were selected as study objects. The patients were divided into control group and observation group using random number table method. Two groups of patients were routinely treated with anti-infective drugs and individualized symptomatic treatment. The control group was given chymotrypsin atomization inhalation on this basis, while the observation group was treated with ambroxol hydrochloride intravenous injection. The therapeutic effect of the two groups were observed and compared. Results The ventilation duration, the times of sputum aspiration by bronchoscope and the number of leukocytes in sputum in the observation group were significantly lower than those in the control group （t=11.667, P〈0.001; t=17.157, P〈0.001; t=8.018, P〈0.001）. The total effective rate of treatment in the observation group was 88.33%, which was significantly higher than that in the control group （76.67%）, and the difference was statistically significant （Z=3.020, P=0.003）. Conclusions In the treatment of ventilator-associated pneumonia in the elderly, ambroxol hydrochloride has good clinical effect and is worth popularizing in clinic.
作者
袁媛
寇心亮
YUAN Yuan;KOU Xinliang(Department of Intensive Medicine,Jilin People＇s Hospital,Changchun 130000,China;The Fourth Prison Districts,Central Hospital of the Prison Administration of Jilin Province,Changchun 130000,China)
出处
《中华灾害救援医学》
2018年第10期564-567,共4页
Chinese Journal of Disaster Medicine
关键词
盐酸氨溴索
老年患者
呼吸机相关性肺炎
疗效
ambroxol hydrochloride
elderly patients
ventilator-associated pneumonia
curative effect
