摘要
目的:观察补肾益气通络化浊方治疗糖尿病肾病早期的临床疗效。方法:将糖尿病肾病早期患者120例,随机分为对照组和治疗组各60例。对照组予常规西医疗法治疗,治疗组在对照组基础上予补肾益气通络化浊方治疗,2组均治疗1年。比较2组临床疗效、治疗前后中医证候积分、空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、24h尿蛋白定量、尿微量白蛋白、尿白蛋白排泄率(UAER)、血清肌酐(SCr)、血尿素氮(BUN)、白细胞介素6(IL-6)、IL-1β、超敏C-反应蛋白(hs-CRP)及终点事件发生率。结果:治疗后,总有效率对照组为65.0%,治疗组为90.0%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组FBG、TC、TG、LDL-C、24h尿蛋白定量、尿微量白蛋白、BUN、SCr、UAER、IL-6、IL-1β、hs-CRP水平均较治疗前降低(P<0.05),治疗组上述指标较对照组降低更明显(P<0.05);2组HDL-C水平均较治疗前升高(P<0.05),治疗组HDL-C水平较对照组升高更明显(P<0.05)。治疗后,终点事件发生率对照组为63.3%,治疗组为18.3%,2组比较,差异有统计学意义(P<0.05)结论:补肾益气通络化浊方治疗糖尿病肾病早期,能降低血糖和血脂水平,减少蛋白尿,改善肾功能,延缓疾病进展。
Objective：To observe the clinical effect of Bushen Yiqi Tongluo Huazhuo prescription for diabetic nephropathy at early stage. Methods：Divided 120 cases of patients with diabetic nephropathy at early stage into the control group and the treatment group randomly,60 cases in each group. The control group received routine western medicine for treatment,while the treatment group was additionally given Bushen Yiqi Tongluo Huazhuo prescription based on the treatment of the control group. The two groups received treatment for one year. Compared the clinical effect,scores of Chinese medicine syndromes,fasting blood glucose（FBG）,triglyceride（TG）, total cholesterol（TC）, low density lipoprotein cholesterol（LDL-C）, high density lipoprotein cholesterol（HDL-C）, 24 h urine protein excretion,urinary microalbumin, urinary albumin excretion rate（UAER）, serum creatinine（SCr）, blood urea nitrogen（BUN）,interleukins-6（IL-6）,IL-1β,high-sensitivity C-reactive protein（hs-CRP）before and after treatment and the incidence of endpoint events in the two groups. Results：After treatment,the total effective rate was 65.0% in the control group and 90.0% in the treatment group,the difference being significant（P〈0.05）. After treatment, levels of FBG, TC, TG, LDL-C, 24 h urine protein excretion, urinary microalbumin, BUN, SCr, UAER, IL-6, IL-1β and hs-CRP in the two groups were decreased when compared with those before treatment（P〈0.05）,and the decrease of the above indexes in the treatment group were more obvious than those in the control group（P〈0.05）. Levels of HDL-C in the two groups were increased when compared with those before treatment（P〈0.05）,and the increase in the treatment group was more obvious than that in the control group（P〈0.05）. After treatment,the incidence of endpoint events was 63.3%in the control group and 18.3% in the treatment group, the difference being significant（P〈0.05）. Conclusion： The therapy of Bushen Yiqi Tongluo Huazhuo prescription
作者
裴文丽
张定华
张东鹏
谢卓霖
樊宇
PEI Wenli;ZHANG Dinghua;ZHANG Dongpeng;XIE Zhuolin;FAN Yu
出处
《新中医》
CAS
2018年第9期98-101,共4页
New Chinese Medicine
基金
国家自然科学基金项目(81460699)
甘肃省自然科学基金项目(1308RJZA202)
国家中医药管理局基金项目(JDZX2015240)
