摘要
目的:探讨右美托咪定对腹腔镜胆囊切除术患者应激反应的影响。方法:将68例择期行腹腔镜胆囊切除术的患者随机分为观察组和对照组,每组各34例。观察组患者麻醉诱导前15min静脉微量泵输注右美托咪定0.4μg/kg,对照组则给予等容量生理盐水进行替代,观察两组患者手术一般情况,记录麻醉诱导前(T0)、气管插管时(T1)、开始气腹时(T2)、拔管时(T3)和拔管5min后5个时间段患者平均动脉血压(MAP)及心率(HR)值,并在各时间段抽取患者静脉血检测血糖、去甲肾上腺素(NE)及皮质醇(Cor)含量。结果:与对照组相比,观察组T1、T2、T3时刻MAP、HR值显著降低,T1、T2、T3、T4时刻NE含量,T2、T3时刻血糖含量,T1、T2、T3时刻Cor含量也显著降低(P<0.05)。结论:右美托咪定可维持患者围术期血流动力学的稳定,减轻腹腔镜胆囊切除术引起的应激反应,值得临床推广使用。
Objective： To investigate the effect of dexmedetomidine on stress response of patients with laparoscopic cholecystectomy. Methods： 68 patients with laparoscopic cholecystectomy were randomly divided into the observation group and the control group, 34 cases in each group. Before anesthesia induction, patients in the observation group were given dexmedetomidine 0.4 μg/kg, while the control group was given an equal volume of saline. The general operation of patients in two groups was observed, mean arterial pressure（MAP）, heart rate （HR）, blood glucose, norepinephrine （NE） and cortisol （Cor） levels before anesthesia induction（T0）, at the moment of tracheal intubation （T1）, immediately began pneumoperitoneum （T2）, immediately began tracheal extubation （T3） and 5min after extubation were recorded. Results： The MAP and HR of the observation group at T1, T2, T3 were significantly higher than those of control group; The NE content at T1, T2, T3, T4, blood sugar levels at T2, T3, Cor content at T1, T2, T3 of the observation group were significantly lower than those of control group （ P 〈0.05）. Conclusion： Dexmedetomidine can maintain the stability of perioperative hemodynamics and alleviate the stress response caused by laparoscopic cholecystectomy, it is worthy of clinical use.
作者
何东海
陈英
吴艳艳
洪道先
He Donghai(Department of Anesthesiology,No.1 Affiliated Hospital of Henan University,Kaifeng 475000)
出处
《数理医药学杂志》
2018年第10期1516-1518,共3页
Journal of Mathematical Medicine
基金
河南大学科研基金项目(编号:2013YBZR027)
