摘要
目的探讨化疗联合髓白1号方对急性髓系白血病患者骨髓上清液白介素-6(IL-6)、转化生长因子β(TGF-β1)、白介素-23(IL-23)、白介素-17(IL-17)的影响。方法 2016年9月—2018年8月对本院住院的36例急性髓系白血病患者随机分为观察组和对照组,两组应用相同的化疗方案化疗,观察组在对照组基础上联合髓白1号方,比较两组治疗前、后的疗效及骨髓上清液IL-6、TGF-β1、IL-23、IL-17。结果 (1)治疗后实验组的完全缓解率高于对照组;(2)治疗后两组IL-6、TGF-β1、IL-23、IL-17降低,且实验组降低显著(P<0.05)。结论化疗联合髓白1号方提高缓解率,可改善急性髓系白血病患者骨髓免疫环境,可干预Th17细胞的增殖、分化的调控作用。
Objective To investigate the effects of chemotherapy combined with medullary 1 prescription on interleukin 6（IL-6）, transforming growth factor β （TGF-β）, interleukin-23 （IL-23） and interleukin-17 （IL-17） in bone marrow supernatant of patients with acute myeloid leukemia. Methods From September 2016 to August 2018, Thirty-six patients with acute myeloid leukemia in our department were randomly divided into two groups（ the observation group and the control group）. Both groups were treated with the same chemotherapy, the observation group was combined with medullary 1 prescription. The curative effect and the levels of bone marrow supernatant IL-6, TGF-β, IL-23 and IL-17 were compared before and after treatment. Results ① the rate of complete remission was higher in the experimental group than in the control group after treatment. ② after treatment the levels of IL-6, TGF-β, IL-23 and IL-17 were decreased in the two groups, and the decrease was more obvious in the experimental group （ P 〈0.05）. Conclusion chemotherapy combined with medullary 1 prescription can improve the remission rate, improve the bone marrow immune environment and interfere the regulation of proliferation and differentiation of Th17 cells.
作者
潘铭
黄建霞
潘筱媛
王燕
吴庆
杜明虎
吴彬章
胡兴江
谢焕荣
PAN Ming;HUANG Jianxia;PAN Xiaoyuan;WANG yan;WU Qing;DU Minghu;WU Bingzhang;HU Xingjiang;XIE Huanrong(Department of Hematology,People s Hospital of Wuwei,Wuwei 733000;Department of Ophthalmology,Rehabilitation Center Hospital of Gansu,Lanzhou 730000,China)
出处
《国外医学（医学地理分册）》
CAS
2018年第3期228-230,共3页
Foreign Medical Sciences：Section of Medgeography
基金
甘肃省自然科学基金项目(No.1606RJZH153)
