摘要
目的探讨注射用鼠神经生长因子联合利培酮治疗儿童孤独症的临床疗效。方法选取我院小儿神经专科收治的65例儿童孤独症患儿,随机分为两组,对照组31例患儿单用利培酮治疗,治疗组34例患儿予注射用鼠神经生长因子联合利培酮治疗。所有患儿均在治疗前和治疗后3个月进行ABC量表、CARS量表评定,对比两组患儿量表评分情况及临床有效率。结果治疗后,治疗组ABC量表中感觉能力、交往能力、运动能力、语言能力及自我照顾5项评分均优于对照组(P<0.05);对照组和治疗组CARS量表总分均比治疗前降低(P<0.05),治疗组与对照组相比,CARS量表总分降低更明显(P<0.05)。治疗组临床有效率为94.11%,高于对照组的77.42%,差异具有统计学意义(P<0.05)。结论注射用鼠神经生长因子联合利培酮较利培酮单药治疗儿童孤独症疗效更佳,不良反应少。
Objective To investigate the clinical efficacy of injection of mouse nerve growth factor combined with risperidone in the treatment of childhood autism.Methods A total of 65 children with autism admitted to our hospital were randomly divided into two groups.31 patients in the control group were treated with risperidone alone,34 patients in the treatment group were treated with injection of mouse nerve growth factor combined with risperidone.AII children were assessed on the ABC scale and CARS scale before treatment and 3 months after treatment,and the scores and clinical effectiveness of the two groups were compared.Results After treatment,the scores of sensory ability,communication ability,exercise ability,language ability and self-care in the ABC scale of the treatment group were better than those of the control group （P〈0.05）,the total scores of CARS scales in the control group and the treatment group were lower than those before treatment （P〈0.05）.Compared with the control group,the total score of the CARS scale was significantly lower in the treatment group（P〈0.05）.The clinical effective rate was 94.11% in the treatment group,which was higher than 77.42% in the control group,the difference was statistically significant（P〈0.05）.Conclusion The injection of mouse nerve growth factor combined with risperidone is better than risperidone in the treatment of childhood autism with less adverse reactions.
作者
周小琳
陈雪贞
李栋方
何展文
罗向阳
ZHOU Xiao-lin;CHEN Xue-zhen;LI Dong-fang;HE Zhan-wen;LUO Xiang-yang(Department of Pediatric Neurology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,Guangdong,China)
出处
《医学信息》
2018年第17期63-65,共3页
Journal of Medical Information
基金
广东省自然博士启动项目(No.2015A030310047)
关键词
注射用鼠神经生长因子
利培酮
儿童孤独症
Mouse nerve growth factor for injection
Risperidone
Childhood autism
