摘要
[目的]探讨中西医结合疗法对于幽门螺杆菌相关性消化性溃疡(peptic ulcer associated with helicobacter pylori,Hp-PU)治疗效果及患者肠道微生态改变的影响。[方法]选择2016年4月~2017年10月该院收治的HpPU患者200例,采取随机数表法分为2组,每组100例,对照组采用泮托拉唑三联疗法(泮托拉唑+克拉霉素+阿莫西林)进行治疗,观察组在三联治疗基础上加用我院自制的中药益气活血汤,治疗1个疗程后,比较2组的疗效及治疗前后患者肠道菌群构成状况。[结果](1)治疗后,观察组Hp-PU症状总积分由(12.1±2.0)分降至(3.2±1.1)分,对照组由(11.8±2.2)分降至(6.8±1.6)分,观察组Hp-PU症状改善水平明显优于对照组(P<0.05);(2)治疗后,观察组Hp清除率为92.0%,显著高于对照组80.0%(P<0.05);(3)治疗后,胃镜检查结果显示,观察组总有效率为93.0%,明显高于对照组的79.0%(P<0.05);(4)与治疗前相比,2组患者治疗后肠道内的阳性杆菌、阴性杆菌及阴性球菌的稀释培养计数(MPN)均显著减少,但阳性球菌MPN并无显著改变;治疗前,2组患者阳性球菌、阳性杆菌、阴性杆菌及阴性球菌的MPN比较差异无统计学意义(P>0.05),治疗后观察组患者肠道内阳性杆菌、阴性杆菌及阴性球菌MPN均明显少于对照组(P<0.05)。[结论]采用活血益气方联合泮托拉唑三联疗法治疗Hp-PU,可有效改善患者症状,促进溃疡面修复,改善患者肠道菌群生态状况,值得临床应用。
[Objective]To investigate the effect of combining traditional Chinese medicine and western therapy on the treatment of Helicobacter pylori associated peptic ulcer and the changes of intestinal microecology in patients.[Methods]A total of 200 patients with Hp-PU were selected from April 2016 to October 2017.They were randomly divided into two groups,100 cases in each group.The control group was treated with pantazolidazole triple therapy.The observation group was treated with Yiqi Huoxue decoction on the basis of triple therapy.After a course of treatment,the curative effect of the two groups and the composition of intestinal flora of the patients＇ treatment were compared.[Results]The total score of peptic ulcer symptom in the observation group decreased from（12.1±2.0）to（3.2±1.1）,and that in the control group decreased from（11.8±2.2）to（6.8±1.6）.The improvement level of the peptic ulcer symptom in the observation group was significantly better than that in the control group（P〈0.05）.The Hp clearance rate in the observation group was 92.0%,which was significantly higher than that in the control group（80.0%,P〈0.05）.The results of gastroscopy showed that the total effective rate of the observation group was 93.0%and 79.0%（P〈0.05）,respectively,higher than that of the control group（79.0%,P〈0.05）.The dilution culture counts of positive bacilli,negative bacilli and negative cocci in the intestinaltract of both groups decreased significantly,but the MPN of positive cocci did not change significantly.There was no significant difference in MPN between negative bacilli and negative cocci（P〉0.05）.The MPN of intestinal positive bacilli,negative bacilli and negative cocci in the observation group was significantly lower than that in the control group（P〈0.05）.[Conclusion]The treatment of peptic ulcer associated with Helicobacter pylori with Huoxue Yiqi recipe combined with pantoprazole can effectively improve the symptoms of the patients,promote the repair of the ulcer surf
作者
李淑红
唐艳萍
LI Shu-hong;TANG Yan-ping(Department of Gastroenterology,Tianjin Nankai Hospital,Tianjin 300100,China)
出处
《中国中西医结合消化杂志》
CAS
2018年第8期673-676,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
中西医结合疗法
幽门螺杆菌相关性消化性溃疡
疗效
肠道微生态改变
影响探讨
integrated traditional chinese medicine and western therapy
helicobacter pylori related peptic ulcer
treatment
intestinal microecology
