摘要
目的探讨替吉奥联合奥沙利铂对中晚期胃癌患者预后及血清胃泌素(GAS)的影响。方法 50例中晚期胃癌患者接受替吉奥联合奥沙利铂术后化疗,2周期后分别评估患者的和血清GAS表达以及不良反应。结果全组化疗有效率为76. 00%,临床症状部分缓解、疾病稳定及疾病进展患者GAS表达依次升高(P <0. 05)。胃癌患者化疗后骨髓抑制、胃肠道反应、肝肾功能异常及外周神经毒性发生率分别为42. 37%、63. 58%、17. 37%、51. 92%。结论替吉奥联合奥沙利铂治疗中晚期胃癌患者预后较好,血清GAS表达明显下降,对临床治疗具有积极的指导意义。
Objective To investigate the effect of S-1 combined with oxaliplatin on prognosis and serum gastrin （GAS） expression of the patients with advanced gastric cancer. Methods Fifty-patients with advanced gastric cancer received the postoperative chemotherapy with 5-1 combined with oxaliplatin, and the prognosis, serum GAS expression and toxicities were observed after two cycles of chemotherapy. Results The effective rate of chemotherapy was 76.00%, the expression of GAS in patients with partial remission, stable disease or disease progression was increased, there were significant differences in the GAS level among the three groups （ P 〈 0.05 ）. The incidences of myelosuppression, gastrointestinal reaction, abnormal liver or kidney function and peripheral nerve toxicity were 42.37%, 63.58%, 17.37% , 51.92%. Conclusion 5-1 combined with oxaliplatin can improve the prognosis of patients with advanced gastric cancer, and decrease the serum GAS expression.
作者
李丽
LI Li(Department of Oncology,the First People＇s Hospital of Suqian,Suqian 223800,China)
出处
《肿瘤基础与临床》
2018年第4期303-305,共3页
journal of basic and clinical oncology
