摘要
目的探讨代谢性疾病相关基因多态性与女性高血压发病的关系,为识别高血压的高危人群提供参考依据。方法基于山东多中心健康管理纵向观察队列,随机抽取2009年9月—2015年12月在山东省千佛山医院健康管理中心参加≥2次健康体检的1240名≥20岁女性构建高血压随访队列,对其进行问卷调查、体格检查、实验室检测和基因型检测,并应用Cox比例风险回归模型探讨单核苷酸多态性(SNP)与女性高血压发病的关系。结果本研究女性高血压随访队列平均年龄为(37.67±10.48)岁,平均随访时间为(27.42±14.77)个月;1 240名±20岁女性中,新发高血压者127例,发病密度为45.47/1 000人年。多因素Cox比例风险回归分析结果显示,在调整了年龄、文化程度、饭菜油腻程度、绝经情况、流产次数、高血压家族史、体质指数、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、血尿酸等混杂因素后,ABCG2-rs2231142(HR=1.448,95%CI=1.090～1.924)、CDKN2A/B-rs10811661(HR=1.357,95%CI=1.052～1.751)和FAM19A1-rs17047586(HR=1.455,95%CI=1.050～2.015)SNPs是女性高血压发病的危险因素,CYP17A1-NT5C2-rs11191548(HR=0.721,95%CI=0.525～0.990)和CDKAL1-rs10946398(HR=0.754,95%CI=0.579～0.981)SNPs是女性高血压发病的保护因素。结论 ABCG2-rs2231142、CDKN2A/B-rs10811661、FAM19A1-rs17047586、CYP17A1-NT5C2-rs11191548和CDKAL1-rs10946398代谢性疾病相关SNPs与女性高血压发病相关。
Objective To explore the relationship between metabolic-related gene polymorphisms and hypertension in northern urban Han Chinese women and to provide a clue for identifying populations at high-risk of hypertension.Methods From the enrollees of the Shandong Multi-Center Longitudinal Cohort for Health Management, we randomly selected 1 240 women aged ≥ 20 years and receiving two or more physical examinations at the Qianfoshan Hospital from September 2009 to December 2015 for a follow-up study. Questionnaire survey, physical examination, laboratory test, and genotyping were performed among the participants. Cox proportional hazard regression model was adopted to investigate the relationship between single nucleotide polymorphisms（SNPs） of metabolic-related genes and the incidence of hypertension.Results The average age of the participants was 37.67 ± 10.48 years and the average follow-up time was 27.42 ± 14.77 months. During the follow-up, 127 participants developed hypertension and the incidence density was 45.47/1 000 personyears in the participants. Multivariate Cox analysis revealed that SNPs of 5 metabolic-related genes were associated with hypertension after adjusting for age,education,consumption of greasy food, menopause,number of abortion,family history of hypertension, body mass index, fasting plasma glucose, total cholesterol, triglyceride, and high-density lipoprotein. The hazard ratios（HRs） and 95 confidence interval（95% CI） of hypertension incidence for the three positively correlated genes were 1.448（1.090-1.924） for ABCG2-rs2231142, 1.357（1.052-1.751） for CDKN2 A/B-rsl0811661, and 1.455（1.050-2.015） for CDKN2 A/B-rs10811661; while, those for the two inversely correlated genes were 0.721（0.525-0.990） for CYP17 Al-NT5 C2-rsl 1191548 and 0.754（0.579-0.981） for CDKAL1-rs10946398, respectively. Conclusion The study results suggest that polymorphisms of ABCG2-rs2231142, CDKN2 A/B-rs10811661, FAM19 A1-rs17047586, CYP17 A1-NT5 C2-rs11191548, and CDKAL1-rs10946398 are corr
作者
刘娅飞
王春霞
许勤勤
于涛
王淑康
袁中尚
刘言训
薛付忠
张成琪
LIU Ya-fei;WANG Chun-xia;XU Qin-qin(Department of Biostatistics,School of Public Health,Shandong University,Ji＇nan,Shandong Province 250010,China)
出处
《中国公共卫生》
CAS
CSCD
北大核心
2018年第9期1198-1203,共6页
Chinese Journal of Public Health
基金
国家自然科学基金(81273082)
山东省自然科学基金(ZR2011HL034)
关键词
高血压
发病
基因多态性
代谢性疾病
女性
hypertension
incidence
gene polymorphism
metabolic disease
female
