摘要
该文对染料木素结构修饰及活性方面的研究进展进行了综述，包括染料木素的糖苷化，烷基化，羟基化，酯化，磺化等多种修饰，并讨论了结构修饰对染料木素生物活性的影响，包括抗肿瘤活性，抑菌活性等。目前，染料木素的结构修饰及衍生主要集中在C-5位酚羟基，C-7位酚羟基以及C-8上，所得的衍生物大多表现出较母体结构更好的生物活性。该文总结了现有结构修饰的不足之处，并对染料木素结构改造的发展方向进行了展望。
In this paper, the progress of modification and activity of genistein was reviewed, including glycosylation, alkylation, hydroxylation, esterification, sulfonation and so on. Furthermore, the effects of structural modification on biological activity such as antitumor and antibacterial activities were discussed. At present, the structural modification and derivation of genistein mainly concentrated on the 5-phenolic hydroxyl, 7-phenolic hydroxyl and C8, and most of the derivatives had better biological activity than genistein. At the same time, the insufficiency of existing structure modification of genistein was summarized, Finally, the development trend of structural modification of genistein was presented.
作者
黄龙江
丁静
HUANG Long-jiang;DING Jing(College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266042,Shandong,China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica and Beijing Union Medical College,Chinese Academy of Medical Sciences,Beo＇ing 100050,China)
出处
《精细化工》
EI
CAS
CSCD
北大核心
2018年第9期1441-1448,1465,共9页
Fine Chemicals
基金
天然药物活性物质与功能国家重点实验室开放课题(GTZK201510)
山东省高校科技计划项目(J16LC13)~~
关键词
染料木素
结构修饰
生物活性
genistein
structure modification
biological activity
