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非动脉炎性前部缺血性视神经病变患者临床特征和视盘形态分析 被引量:8

Clinical characteristics and optic disc morphology of patients with non-arteritic anterior ischemic optic neuropathy
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摘要 目的分析非动脉炎性前部缺血性视神经病变患者临床特征及视盘参数,探讨其病变特征。方法回顾分析2017年1月至2017年12月在山西省眼科医院确诊为首次发病的非动脉炎性前部缺血性视神经病变患者77例77眼,另外选取同期于我院就诊的健康人69名为对照组。记录其人口学特征、眼科常规检查、眼眶磁共振成像(MRI)检查和血清学检查,应用Optvue光相干断层扫描仪(OCT)行视盘光相干扫描,对其视盘参数进行分析。结果病例组和对照组在高血压史、高脂血症、视杯面积、视盘面积、杯/盘面积比差异有统计学意义(P<0.05)。高血压史、收缩压、甘油三酯、总胆固醇(TC)、空腹血糖(FBG)、视盘面积、杯/盘面积比是非动脉炎性前部缺血性视神经病变的独立危险因素。病例组全周视网膜神经纤维层(RNFL)厚度均显著高于对照组(P<0.05),病例组各象限神经纤维层水肿厚度差异无统计学意义(P>0.05)。结论高血压史、收缩压、甘油三酯、TC、FBG、视杯面积、杯/盘面积比是非动脉炎性前部缺血性视神经病变的危险因素。非动脉炎性前部缺血性视神经病变的视盘水肿各象限无差异。 Objective To investigate the clinical characteristics and optic disc parameters in patients with non- arteritie anterior isehemie optic neuropathy (NAION) and its pathological features. Methods A retrospective analysis was performed of 77 patients (77 eyes)with first-onset NAION diagnosed in Shanxi Eye Hospital between January 2017 and December 2017. A cohort of 69 healthy individuals who visited our hospital during the study period was enrolled as the control group. The demographic characteristics and findings of routine ophthalmic examination, orbital magnetic resonance imaging (MRI) and serological studies were recorded. Optvue optical coherence tomography was performed to investigate the optic disc parameters. Results There were significant differences in the history of hypertension, hyperlipidemia, FBG cup area, optic disc area, and cup-to-disc area ratio between the NAION group and the control group (P〈0.05). A history of hypertension or hyperlipidemia, cup area, optic disc area, and cup-to-disc area ratio were found to be independent risk factors for NAION. The NAION group showed greater thickness of retinal nerve fiber layer (RNFL) with significant difference compared with the controls (P〈0.05). However, there was no statistical differences in the thickness of the edema of the nerve fiber layer at each eye quadrant between the two groups (all P〉0.05). Conclusion A history of hypertensive ,TG, TC、 FBG optic disc area, cup area, and cup-to-disc area ratio are risk factors for NAION. There is no difference in optic disc edema among eye quadrants in NAION.
作者 吴子旭 郑东萍 潘陆平 Dong Jingyan Xie Jun Ren Yan Wu Zixu;Zheng Dongping;Pan Luping;Dong Jingyan;Xie Jun;Ren Yan(Department of Fundus Diseases,Shanxi Provincial Eye Hospital,Taiyuan 030002,China)
出处 《中国药物与临床》 CAS 2018年第9期1490-1492,共3页 Chinese Remedies & Clinics
关键词 视神经病变 缺血性 视盘 危险因素 光相干断层扫描 Optic neuropathy Ischemic Optic disc Risk factors OCT
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