摘要
目的探讨热毒宁联合阿奇霉素治疗小儿肺炎支原体肺炎(MP)的临床疗效。方法选择2016年1月至2017年5月解放军第一六一医院收治的80例MP患儿为研究对象,依据随机数字法分为两组:对照组(37例)给予阿奇霉素注射液10 mg/kg静脉滴注,每日1次;观察组(43例)在对照组基础上加用热毒宁注射液0.5 m L/kg静脉滴注,每日1次。两组均连续治疗7 d。比较两组患儿的临床疗效、临床症状、体征消失时间、两组患儿不良反应发生情况及患者炎性因子水平。结果观察组总有效率高于对照组[93.02%(40/43)比75.68%(28/37),P<0.05]。观察组患儿发热时间、咳嗽时间、气喘时间、肺部啰音消失时间均短于对照组[(44.2±27.6)h比(58.3±19.5)h、(4.4±1.2)d比(9.7±2.5)d、(3.1±1.2)d比(7.3±2.1)d、(53.1±11.3)h比(98.7±22.9)h](P<0.01)。治疗后观察组患者炎性因子水平肿瘤坏死因子α、白细胞介素4、Ig E均低于对照组[(1.43±0.19)g/L比(2.49±0.21)g/L、(113.66±20.47)ng/L比(136.43±20.19)ng/L、(109.38±20.56)k U/L比(137.69±23.35)k U/L](P<0.01)。结论热毒宁联合阿奇霉素治疗能有效提高MP患儿的临床疗效,缩短其临床症状及体征的持续时间,且不良反应发生率与单用阿奇霉素方案治疗无差异。
Objective To investigate the effect of Reduning（RDN） combined with azithromycin on children with mycoplasma pneumoniae pneumonia. Methods A total of 80 children with mycoplasma pneumoniae pneumonia in PLA 161st Hospital were included from Jan.2016 to May 2017,and were randomly divided into two groups：an observation group（ n =43）and a control group（ n =37）.In the control group,azithromycin injection 10 mg/kg was given intravenously once a day,while in the treatment group,0.5 mL/kg of RDN was added,once a day intravenously.Both groups were treated continuously for 7 days.The clinical efficacy,clinical symptoms,time of disappearance of signs,the occurrence of adverse reactions and the level of inflammatory factors were compared between the two groups. Results The total effective rate of the observation group was higher than that in the control group[93.02%（40/43） vs 75.68% （28/37）, P 〈0.05].The fever time,cough time,asthma time,lung rale disappearing time of the observation group were less than those of the control group [（44.2± 27.6） h vs （58.3± 19.5 ） h,（4.4±1.2） d vs （9.7±2.5） d,（3.1±1.2） d vs （7.3±2.1） d,（53.1± 11.3 ） h vs （98.7±22.9） h]（ P 〈0.01）.After treatment,the levels of tumor necrosis factor α, interleukin 4,IgE in the observation group were lower than those in the control group[（1.43±0.19） g/L vs （2.49± 0.21） g/L ,（113.66± 20.47） ng/L vs （136.43±20.19） ng/L,（109.38±20.56） kU/L vs （137.69±23.35） kU/L] （ P 〈0.01）.
Conclusion The treatment of RDN combined with azithromycin can effectively improve the clinical efficacy and shorten the duration of clinical symptoms and signs in children with mycoplasma pneumoniae pneumonia,and the incidence of adverse reactions is not different from that of azithromycin alone.
作者
张帆
高金星
ZHANG Fan;GAO Jinxing(Department of Pediatrics,PLA 161st Hospital,Wuhan 430010,China)
出处
《医学综述》
2018年第17期3533-3537,共5页
Medical Recapitulate
关键词
小儿肺炎支原体肺炎
热毒宁
阿奇霉素
Mycoplasma pneumoniae pneumonia in children
Reduning
Azithromycin
