摘要
目的探讨腹腔热灌注联合化学治疗对晚期卵巢癌临床疗效影响。方法选择2015年5月—2017年12月晚期卵巢癌患者120例,信封法随机分为热疗组与对照组。对照组患者给予吉西他滨与奥沙利铂联合化疗。热疗组患者在此基础上给予腹腔热灌注治疗。以腹水控制情况观察两组患者临床疗效。采用流式细胞仪检测外周血CD4^+CD25^+T淋巴细胞比例水平变化。结果治疗后,热疗组患者腹水控制有效率高于对照组,热疗组患者血清CA125、外周血CD4^+CD25^+T淋巴细胞比例水平下降,。结论腹腔热灌注联合化疗可以解除机体肿瘤免疫抑制状态,促进晚期卵巢癌患者腹水吸收,改善临床预后。
Objective：To investigate the effect of intraperitoneal thermal perfusion combined with chemical therapy on the patients with advanced ovarian cancer.Methods：120 patients with advanced ovarian cancer from May 2015 to December2017 were selected,and by the envelope method they was randomly divided into hyperthermia group and control group.The patients in the control group were treated with the combination of gemcitabine and oxaliplatin.The patients in the hyperthermia group were treated with intraperitoneal heat perfusion on this basis.The clinical effect of two groups of patients was observed with the index of the control of ascites.The changes of serum CA125 and peripheral CD4^＋CD25^＋T lymphocyte proportion between the two groups were compared before and after treatment.Results：After treatment,the effective rate of ascites control in the hyperthermia group was higher than that of the control group.The levels of serum CA125 and peripheral blood CD4^＋CD25^＋T lymphocyte in the hyperthermia group were decreased.Conclusion：Intraperitoneal heat perfusion combined with chemotherapy can relieve the state of tumor immune suppression and promote the absorption of ascites in advanced ovarian cancer patients and improve the clinical prognosis.
作者
李国松
李文慧
LI Guo-song;LI Wen-hui(Dept.of Gynaecology,Zhoukou Peopleg Hospital,Zhoukou 466000,China;Zhoukou East New District Peopleg Hospital,Zhoukou 466000,China)
出处
《泰山医学院学报》
CAS
2018年第10期1117-1118,共2页
Journal of Taishan Medical College
关键词
晚期
卵巢癌
免疫抑制
腹腔热灌注
advanced
ovarian cancer
inmmnosuppression
intraperitoneal heat perfusion
