摘要
目的探讨外周血中性粒细胞与淋巴细胞比值(NLR)在恶性胸腔积液中的变化及其临床价值。方法收集恶性胸腔积液患者50例(恶性胸腔积液组),良性胸腔积液患者50例(良性胸腔积液组)。检测所有研究对象的外周血细胞计数,比较NLR在良恶性胸腔积液患者间的差异。结果恶性胸腔积液组的NLR值较良性胸腔积液组明显升高,差异有统计学意义(P<0.05)。ROC曲线分析,NLR值的最佳阈值为2.14,AUC为0.77,灵敏度为76.8%,特异度为86.7%。结论 NLR测定是恶性胸腔积液诊断的敏感指标,具有较高的特异性,对恶性胸腔积液的诊断有一定的临床价值。
Objective To investigate the changes of neutrophil and lymphocyte ratio（ NLR） in peripheral blood and its clinical value in malignant pleural effusion. Methods Fifty cases of malignant pleural effusion（ malignant pleural effusion group） and fifty cases of benign pleural effusion（ benign pleural effusion grouup） were collected. The peripheral blood cell counts of all subjects were examined,and the differences of NLR between benign and malignant pleural effusion patients were compared.Results The NLR value of patients with malignant pleural effusion was significantly higher than that of benign pleural effusion,and the difference was statistically significant（ P〈0. 05）. ROC curve analysis showed that the optimal threshold of NLR was 2. 14,AUC was 0. 77,sensitivity was 76. 8%,and the specificity was 86. 7%. Conclusion NLR determination is a sensitive indicator of malignant pleural effusion,and has a high specificity; the diagnosis of malignant pleural effusion has a certain clinical value.
作者
韦文君
孙青阳
张婴嫱
曾贤铭
成军
孙长贵
WEI Wen-jun;SUN Qing-yang;ZHANG Ying-qiang;ZENG Xian-ming;CHENG Jun;SUN Chang-gui(Clinical Laboratory,the 117th Hospital of PLA,Hangzhou,Zhejiang 310004,China)
出处
《中国卫生检验杂志》
CAS
2018年第16期1996-1997,2000,共3页
Chinese Journal of Health Laboratory Technology
