摘要
目的探讨早期胰岛素治疗妊娠期糖尿病(GDM)母婴围产结局。方法随机选取2014年12月至2016年12月GDM患者150例,以孕妇进行胰岛素治疗起始孕周分组,于<32孕周治疗者75例为早期组,于≥32孕周治疗者75例为晚期组。记录并比较两组孕妇初诊及分娩前1周时空腹血糖(FBG)和餐后2 h血糖(2 hPG)水平,分析两组母婴围产结局。结果初诊及分娩前1周时,两组孕妇FBG、2 hPG水平比较差异未见统计学意义(P>0.05);分娩前1周时,两组孕妇FBG、2 hPG水平均低于初诊时(P<0.01),且基本维持在正常范围内。早期组母婴不良围产结局率为8.00%(6/75),晚期组为21.33%(16/75),两组比较差异有统计学意义(χ~2=5.33,P<0.01)。结论于<32孕周行早期胰岛素治疗GDM能有效调节孕妇血糖水平,减少母婴不良围产结局,可临床推荐应用。
Objective To investigate the pregnancy outcomes in early pregnancy women with insulin treatment for gestational diabetes mellitus（ GDM）. Methods A total of 150 patients with GDM from December 2014 to December 2016 were randomly selected,and they were divided into two groups by the insulin treatment at different initial gestational age. The 75 patients who treated by insulin treatment at 32 gestational age were taken as the early group,and the 75 patients who treated by insulin treatment at ≥32 weeks gestational age were taken as the late group. The fasting blood glucose（ FBG）and postprandial 2 h blood glucose（ 2 h PG） levels of the two groups were recorded and compared at the first visit and 1 week before delivery,and the pregnancy outcome of the two groups was analyzed.Results There was no significant difference in the levels of FBG and 2 h PG between the two groups at the first week and 1 week before delivery（ P〈0. 05）. At 1 week before delivery,the average FBG and 2 h PG water in two groups of pregnant women were lower than those at the first visit（ P〈0. 01）,and which were basically maintained in the normal range. In the early group,the maternal and infant bad pregnancy outcome was 8%（ 6/75）,and the late group was 21. 33%（ 16/75）. The difference between the two groups was significant（ χ^2= 5. 33,P〈0. 01）. Conclusions Insulin therapy for GDM in early pregnancy can effectively regulate the blood glucose level of pregnant women and reduce the adverse pregnancy outcomes of mothers and infants,which can be recommended for clinical application.
作者
马向莉
Ma Xiangli(Department of Gynecology,Gongyi People＇s Hospital,Gongyi 451200,China)
出处
《临床医学》
CAS
2018年第8期33-35,共3页
Clinical Medicine
关键词
胰岛素
妊娠期糖尿病
血糖控制
母婴结局
Insulin therapy
Gestational diabetes mellitus
Blood sugar level
Pregnancy outcome
