摘要
系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种临床表现多样的异质性自身免疫性疾病,该病严重危害人类健康,发病机制尚未明确。现有的激素和免疫抑制疗法因存在毒副作用而限制其临床应用。中药以其高效低毒、协同作用强等优势,为SLE的中药防治提供了良好前景。该文将对几种典型的中药活性成分,包括苷类、多糖类、萜类、生物碱类、黄酮类等对SLE的干预作用及机制做一综述。
Systemic lupus erythematosus（SLE） is a heterogeneous autoimmune disease with a variety of clinical manifestations. It causes serious crisis to human health and its pathogenesis is not clear yet. The clinical application of hormone and immunosuppressive therapy is often limited by the toxic and side effects. With the advantages of high efficiency, low toxicity and strong synergistic effect,traditional Chinese medicine（TCM） provides a good prospect for the prevention and treatment of SLE. In this paper, the intervention effect and mechanisms of several typical active ingredients of TCM on SLE, including glycosides, polysaccharides, terpenoids, alkaloids and flavonoids are reviewed.
作者
陈嘉怡
郭星雨
贾虎
陈虹
李覃
CHEN Jia-yi;GUO Xing-yu;JIA Hu;CHEN Hong;LI Tan(Postgraduate Department,Logistics University of PAP,Tianjin 300309,China)
出处
《武警后勤学院学报（医学版）》
CAS
2018年第1期65-69,共5页
Journal of Logistics University of PAP（Medical Sciences）
基金
天津市应用基础与前沿技术研究计划重点项目(14JCZDJC36700)
武警后勤学院科研基金项目(WHJ2016013)
关键词
系统性红斑狼疮
中药
炎症反应
免疫调节
T细胞
Systemic lupus erythematosus
Traditional Chinese medicine
Inflammatory reactions
Immune regulation
T lymphoeytes
