摘要
目的探讨双水平气道正压通气(Bi PAP)对阻塞性睡眠呼吸暂停综合征(OSAHS)合并代谢综合征(MS)患者视黄醇结合蛋白4(RBP4)、心踝指数(CAVI)的影响。方法收集368例OSAHS合并MS患者,按治疗方法分为对照组及Bi PAP治疗组;选择同期正常人群110例作为健康志愿组。给予对照组常规药物治疗,Bi PAP治疗组在此基础上加用Bi PAP治疗。比较健康志愿组、对照组与OSAHS合并MS组临床基线资料以及对照组和Bi PAP治疗组治疗前后AHI、RBP4、CAVI水平。结果 OSAHS合并MS组收缩压、舒张压、空腹血糖、总胆固醇、低密度脂蛋白、肌酐、高密度脂蛋白、甘油三酯、AHI、RBP4及CAVI高于健康志愿组,差异有统计学意义(P<0.05)。对照组及Bi PAP治疗组基线资料差异无统计学意义(P>0.05)。治疗6个月后,Bi PAP治疗组AHI、RBP4、CAVI均低于对照组,差异有统计学意义(P<0.05)。结论 Bi PAP可能通过降低RBP4、CAVI水平,达到减缓动脉硬化进程及改善临床预后的目的。
Objective To investigate the effects of Bi PAP on retinol binding protein 4（ RBP4） and cardiac ankle index（ CAVI） in OASHS patients with metabolic syndrome（ MS）. Methods Three hundred and sixty-eight cases of OSAHS with MS were randomly divided into the control group and Bi PAP treatment group. One hundred and ten normal subjects were selected as healthy volunteers. The control group was given conventional drug treatment,and on this basis,the Bi PAP treatment group was given Bi PAP treatment. The clinical baseline data of healthy volunteer group,control group and OSAHS treatment group were compared,and the levels of AHI,RBP4,CAVI before and after treatment in control group and Bi PAP treatment group were compared. Results The OSAHS patients with MS had higher systolic blood pressure,diastolic blood pressure,fasting blood glucose,total cholesterol,low density lipoprotein,creatinine,high density lipoprotein,triglyceride,AHI,RBP4 and CAVI than the healthy volunteer group（ P〈0. 05）. There was no significant difference in baseline data between the control group and the Bi PAP treatment group（ P〉0. 05）. After 6 months of treatment,the levels of AHI,RBP4 and CAVI were lower in the Bi PAP treatment group than that in the control group（ P〈0. 05）. Conclusion Bi PAP may slow the progression of arteriosclerosis and improve the clinical prognosis by reducing the level of RBP4 and CAVI.
作者
王娜
杜林翔
Wang Na;Du Linxiang(Department of Cardiovascular Medicine,Zhoukou Central Hosital,Zhoukou 466001,China)
出处
《河南医学研究》
CAS
2018年第12期2140-2143,共4页
Henan Medical Research
