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万古霉素个体化给药流程的建立及案例分析 被引量:13

Establishment of the individualized drug delivery flow path of vavomycin and case analysis
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摘要 目的:建立万古霉素个体化给药流程,并将其应用于临床实践。方法:临床药师依据万古霉素血药浓度监测结果和患者情况,应用建立的流程协助临床制定万古霉素初始给药方案,运用JPKD-vancomycin下的万古霉素群体药动学模型,结合贝叶斯反馈程序解读血药浓度监测结果、推算患者个体化给药剂量、预测调整后给药方案的血药浓度结果,有助于万古霉素个体化给药。结果:万古霉素个体化给药流程应用于万古霉素血药浓度的解读,为临床制定万古霉素个体化给药方案提供依据。结论:建立了万古霉素个体化给药流程,有助于协助临床合理用药,可提高万古霉素临床疗效和减少相关不良反应发生。 OBJECTIVE To establish the individualized drug delivery flow path of vacomycin,and apply in clinical practice.METHODS Combined with the vancomycin population pharmacokinetics model and Java PK for Desktop,the flow path was established. The initial dosage of vancomycin was calculated for the initial predicted trough concentration of vancomycin based on the patient's information. Then actual drug doses and predicted serum steady trough concentration of vancomycin were calculated by Bayesian,which was helpful for vancomycin individualization. RESULTS The individualized drug delivery flow path of vancomycin was applied for the interpretation of trough concentration,which could provide basis for the establishment of vancomycin individualized dosing regimens. CONCLUSION The individualized drug delivery flow path of vacomycin is established,which can help assist clinical individualized application of vancomycin,improve the effect and reduce the relative adverse raections of vancomycin.
作者 赖珺 李欣晴 吴丽丽 廖晓飞 LAI Jun;LI Xin-qing;WU Li-li;LIAO Xiao-fei(Department of Pharmacy,The People' s Hospital of Ganzhou,Jiangxi Ganzhou 341000,China)
出处 《中国医院药学杂志》 CAS 北大核心 2018年第15期1656-1660,共5页 Chinese Journal of Hospital Pharmacy
基金 江西省卫生计生委科技计划项目(编号:20174044)
关键词 万古霉素 治疗药物浓度监测 群体药动学 流程 JPKD vancomycin therapeutic drug monitoring population pharmacokinetics flow path Java PK for Desktop
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