摘要
目的观察消癌平注射液联合XELOX方案治疗晚期结直肠癌的疗效及不良反应。方法选取2015年4月至2016年10月确诊的晚期结直肠癌患者82例,按治疗方法分为两组,XELOX组应用XELOX方案化疗(n=36),消癌平+XELOX组应用消癌平注射液联合XELOX方案化疗(n=46),治疗过程中观察患者化疗不良反应,并于治疗2个周期后进行疗效评价。结果 XELOX组患者有效率为44.4%,消癌平+XELOX组有效率为67.4%,两组治疗有效率差异有统计学意义(P<0.05)。依据KPS评分标准,消癌平+XELOX组患者生活质量改善情况明显优于XELOX组(P<0.05)。消癌平+XELOX组的白细胞降低、恶心、呕吐、神经毒性明显低于XELOX组(P均<0.01)。结论消癌平联合XELOX方案化疗较单纯XELOX方案化疗可明显提高近期化疗效果,改善患者生活质量,减少毒副反应,具有增效减毒的作用。
Objective To observe the clinical efficacy and adverse reactions of Xiao-Ai-Ping injection combined with XELOX regimen in the treatment of advanced colorectal cancer. Method Eighty-two patients with definite diagnose of advanced colorectal cancer from April 2015 to October 2016 were recruited in this study and divided into control group and case group. Capecitabine combined with oxaliplatin（XELOX） regimen was performed in control group（n = 36）,and XiaoAi-Ping injection was added based on XELOX regimen in case group（n = 46）. The adverse reaction was observed during chemotherapy,and the curative effect was evaluated after 2 cycles of treatment. Results The effective rate in case group was significantly higher than that in control group（67. 4% vs 44. 4%,P〈0. 05）. According to the Karnofsky performance status（KPS） score,the quality of life in case group was significantly better than that in control group（P〈0. 05）. The incidence rates of leukocyte reduction,nausea,vomiting and neurotoxicity in case group were significantly lower than those in control group（P〈0. 01）. Conclusion The chemotherapy of Xiaoping combined with XELOX regimen can obviously increase the short-term curative effect of chemotherapy,improve the patient＇s life quality,reduce the side reactions and have the effect of increasing the efficiency and reducing the toxicity.
作者
万晓龙
郑彩霞
王亚利
林帅
董水滢
WAN Xiao-long;ZHENG Cai-xia;WANG Ya-li;LIN Shuai;DONG Shui-ying(Department of Gastroenterology,The Second Affiliated Hospital of Xi＇an Jiaotong University,Xi＇an,Shaanxi 710004,China)
出处
《中国临床研究》
CAS
2018年第8期1072-1074,共3页
Chinese Journal of Clinical Research
关键词
晚期结直肠癌
消癌平
化学疗法
XELOX方案
毒副反应
Advanced colorectal cancer
Xiao-Ai-Ping
Chemothera peutic
XELOX regimen
Toxic and adversereaction
