摘要
中枢神经系统脱髓鞘疾病以多发性硬化(MS)和视神经脊髓炎谱系疾病(NMOSDs)最常见。在MS及NMOSD急性期,激素、静脉注射大剂量免疫球蛋白、血浆置换似乎都是有效的疗法;而在缓解期,免疫调节剂和免疫抑制剂为MS的常规治疗药物,此外单克隆抗体、静脉注射免疫球蛋白G、雌激素、他汀类药物、疫苗接种及中医中药等治疗也被逐渐运用于临床。小剂量激素和免疫抑制剂的联合维持治疗将使NMOSD患者得到更大获益。由于发病机制的不同,MS和NMOSD在治疗上存在明显差异。现就二者的临床治疗进展进行综述。
Both multiple sclerosis （MS） and neuromyelitis optica spectrum disorders （NMOSDs） are the most common demyelinating diseases of the Central Nervous System. Hormone,intravenous immuno- globulin and plasma exchange seem to be an effective therapy during MS and NMOSD acute phase ;however, immunomodulators and immunosuppressive agents are conventional treatments for MS in the remission peri- od,in addition monoclonal antibody, intravenous immunoglobulin G, estrogen, statins, vaccination and tra- ditional Chinese medicine have also been gradually applied to clinical practice. Combined maintenance ther- apy with low-dose hormones and immunosuppressive agents will benefit NMOSD patients. Because of the dif- ferent pathogenesis, MS and NMOSD have obvious differences in treatment. This review mainly focus on progress in clinical treatment of muhiple sclerosis and neuromyelitis optica spectrum disorders .
作者
刘代强
郝延磊
Liu Daiqiang;Hao Yanlei(Graduate School of Jining Medical University,Jining 272000,Chin;Department of Neurology,Affiliated Hospital of Jining Medical University,Jining 272029,China)
出处
《中国医师杂志》
CAS
2018年第8期1260-1266,共7页
Journal of Chinese Physician
基金
国家自然科学基金(81271398
81141054)~~
