摘要
目的研究神经内镜下经蝶手术治疗巨大侵袭性垂体腺瘤的临床效果。方法选取2015年3月~2017年1月石家庄市第一医院收治的巨大侵袭性垂体腺瘤患者76例。根据随机数字表法分为观察组(n=39)与对照组(n=37)。观察组采用神经内镜下经蝶手术治疗,对照组采用经颅显微镜手术治疗。对两组患者进行为期1年的随访观察,比较两组各项临床指标水平:全切率、术后症状缓解率、术后并发症发生率、肿瘤残留率以及复发率。结果观察组手术时间、术后住院时间均短于对照组,术中失血量少于对照组,术后并发症发生率、肿瘤残留率及复发率均低于对照组,而全切率、术后症状缓解率均高于对照组,差异均有统计学意义(均P<0.05)。结论神经内镜下经蝶手术治疗巨大侵袭性垂体腺瘤临床效果明显,可有效缩短手术时间,减少出血量,促进患者早日康复,同时有效降低术后并发症发生率以及肿瘤残留率、复发率,安全性较好,值得临床推广应用。
Objective To study the clinical effect of endoscopic transsphenoidal surgery in the treatment of giant invasive pituitary adenoma. Methods A total of 76 patients with giant invasive pituitary adenoma admitted to the First Hospital of Shijiazhuang from March 2015 to January 2017 were selected. They were divided into observation group（39 cases）and control group（37 cases） according to digital random table method. The observation group was treated with neuroendoscopic transsphenoidal surgery, and the control group was treated with transcranial microscopy. The patients in the two groups were followed up for 1 year, and the clinical indicators, such as total cut rate, postoperative symptom remission rate, postoperative complications rate, tumor residual rate and recurrence rate were compared. Results The operation time and postoperative hospitalization time of the observation group were shorter than those of the control group,the intraoperative blood loss was less than the control group, and incidence of postoperative complications, tumor residual rate and recurrence rate were lower than those of the control group, while the total incision rate and postoperative symptom remission rate were higher than those of the control group, with statistically significant differences（all P〈0.05）. Conclusion Neuroendoscopic transsphenoidal surgery has obvious clinical efficacy in the treatment of giant invasive pituitary adenoma, which can effectively shorten the operation time, reduce the amount of bleeding, promote the early recovery of patients, and effectively reduce the incidence of postoperative complications, as well as the residual rate and recurrence rate of tumors, which are safe and worthy of clinical application.
作者
屈浙
田军
胡昱红
苏白玉
王坤
檀浩鹏
李建华
QU Zhe;TIAN Jun;HU Yuhong;SU Baiyu;WANG Kun;TAN Haopeng;LI Jianhua(Department of Neurosurgery,the First Hospital of Shijiazhuang,Hebei Province,Shijiazhuang 050000,China;Department of Medical Insurance,the First Hospital of Shijiazhuang,Hebei Province,Shijiazhuang 050000,China;Department of Endocrine,the First Hospital of Shijiazhuang,Hebei Province,Shijiazhuang 050000,China)
出处
《中国医药导报》
CAS
2018年第23期49-51,55,共4页
China Medical Herald
基金
河北省石家庄市科学技术研究与发展指导计划项目(171461563)
关键词
侵袭性垂体腺瘤
神经内镜
经蝶手术
并发症
复发率
Giant invasive pituitary adenoma
Endoscopic
Transsphenoidal surgery
Complications
Recurrence rate
