摘要
目的:制备辛夷挥发油壳聚糖微球和优选制备工艺。方法:采用复乳-乳化交联法制备辛夷挥发油壳聚糖微球,以粒径、包封率、载药量为评价指标,通过单因素试验考察壳聚糖浓度、投药量、油水比、搅拌速度对制备工艺的影响,并设计正交试验优化制备工艺。结果:微球最佳制备工艺为:壳聚糖浓度为3%,辛夷挥发油和壳聚糖比例为1,油水体积比为4,搅拌速度为600r/min。所得微球粒径分布在30~70μm为69.37%,载药量为6.03%,包封率为28.66%。通过光学显微镜和电镜扫描,可看到微球球形圆整,分布均匀。结论:辛夷挥发油壳聚糖微球最优制备工艺稳定可行。
Objective：To prepare the chitosan microsphere of the volatile oil of Magnoliae Flos and optimize the preparation process.Methods：The chitosan microspheres of volatile oil of Magnoliae Flos were prepared by the multiple emulsion cross-linking method,setting the particle size,drug loading,encapsulation efficiency as evaluation indexes,the effects of chitosan concentration,dosage,oil-water ratio and stirring speed on the preparation process were investigated by single factor test,and the orthogonal experiment was also designed to optimize the preparation process.Results：The optimal preparation process of microspheres was as follows：the concentration of chitosan was 3%,the feed ratio of the volatile oil of magnoliae flos and chitosan was 1,the ratio of oil to water was 4,and the stirring speed was 600 r/min,and.The particle size distribution of the microspheres was 69.37%,the drug loading was 6.03%,and the encapsulation efficiency was 28.66%.Through the optical microscope and the scanning electron microscope,the microspheres were regular round in its morphology and evenly distributed.Conclusion：The optimum preparation process of the volatile oil of Magnoliae Flos chitosan microspheres is stable and feasible.
作者
叶俊贤
崔彩红
崔升淼
Ye Junxian;Cui Caihong;Cui Shengmiao(College of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China)
出处
《亚太传统医药》
2018年第8期47-50,共4页
Asia-Pacific Traditional Medicine
基金
国家自然科学基金青年基金项目(81302715)
关键词
辛夷挥发油
壳聚糖微球
正交试验
制备工艺
Volatile Oil of Magnoliae Flos
Chitosan Microspheres
Orthogonal
Preparation process
