摘要
目的探讨卡前列素氨丁三醇预防瘢痕子宫产后出血的疗效及药物经济性。方法回顾性分析120例瘢痕子宫产妇的临床资料,按照治疗方法不同分为试验1组(37例)、试验2组(23例)和对照组(60例)。待胎儿娩出后立即为三组产妇子宫注射缩宫素,然后试验1组肌注国产卡前列素氨丁三醇250μg,试验2组肌注进口卡前列素氨丁三醇250μg,对照组产妇肌注生理盐水1 m L。比较三组产妇的疗效及药物经济性。结果试验1、2组产妇产后0.5 h、2 h及24 h出血量均少于对照组(P<0.05);试验1、2组的产后出血率、产后输血率及子宫切除率均低于对照组(P<0.05);试验1组和对照组的治疗总费用均低于试验2组(P<0.05);试验2组的消化道反应及头痛发生率明显低于试验1组(P<0.05)。结论国产与进口卡前列素氨丁三醇预防瘢痕子宫产后出血的疗效均显著,能够显著减少产妇产后出血风险,并且国产药品更加经济实惠。
Objective To investigate the efficacy of carboprost tromethamine on prevention of postpartum hemorrhage of scar uterus and drug economy. Methods The clinical data of 120 pregnant women with scars uterus were retrospectively analyzed. According to different treatment methods, they were divided into experimental group 1（37 cases）, experimental group 2（23 cases） and control group（60 cases）. After the fetus was delivered, the three groups of women were immediately injected with oxytocin, then the experimental group 1 was intramuscularly injected with 250 μg of domestic carboprost tromethamine, the experimental group 2 was intramuscularly injected with 250 μg of imported carboprost tromethamine, and the control group was intramuscularly injected with 1 m L of normal saline. The efficacy and drug economy of the three groups were compared. Results At 0.5 h, 2 h and 24 h after delivery, the volume of postpartum hemorrhage in the experimental group were less than those in the control group（P〈0.05）. The postpartum hemorrhage rate, postpartum blood transfusion rate and hysterectomy rate in the experimental group were lower than those in the control group（ P〈0.05）. The total treatment costs of the experimental group 1 and the control group were significantly lower than that of the experimental group 2（P〈0.05）. The incidence of digestive tract reactions and headache in the experimental group 2 were significantly lower than those in the experimental group 1（P〈0.05）. Conclusion Domestic and imported carboprost tromethamine have a significant effect on the prevention of postpartum hemorrhage in scarred uterus. It can significantly reduce the risk of postpartum hemorrhage, and domestically produced drugs are more economical.
作者
鲁会英
王彩英
续靖宁
雷菊玲
LU Hui-ying, WANG Cai-ying, XU Jing-ning, LEI Ju-ling(Northwestern Women and Children Hospital, Xi＇an 710061, China)
出处
《临床医学研究与实践》
2018年第24期149-150,共2页
Clinical Research and Practice
