摘要
目的探讨乳腺癌患者磁共振(MRI)T_2WI信号特征与细胞核增殖抗原(Ki-67)表达的相关性。方法采用回顾性与随机抽样研究方法,选取2011年9月-2017年4月在该院诊治的乳腺癌患者122例作为研究对象,记录MRI T_2WI信号特征与扩散加权成像(DWI)表观弥散系数(ADC)值,采用免疫组织化学检测Ki-67阳性表达情况。结果癌组织的Ki-67阳性率为54.9%,癌旁组织为23.8%,癌组织的Ki-67阳性率高于癌旁组织(P<0.05)。在T_2WI信号特征上,癌组织78例(63.9%)主要表现为高信号与高亮信号,癌旁组织9例(7.4%)主要表现为低或等信号。癌组织的ADC值为(0.89±0.12)×10^(-3)/mm^2,低于癌旁组织的(1.67±0.24)×10^(-3)/mm^2(P<0.05)。在癌组织中,Spearman相关性系数分析显示T_2WI高信号与Ki-67阳性率呈正相关(r_s=0.724,P<0.05),与ADC值呈负相关(r_s=-0.452,P<0.05)。多因素分析T_2WI高信号、ADC值为影响Ki-67阳性率的危险因素(P<0.05)。结论乳腺癌病灶MRI T_2WI信号特征多表现为高信号,Ki-67呈现高阳性率表达,伴随有ADC值下降,它们之间存在相关性,T_2WI信号特征对乳腺癌的筛查及预后判断有积极作用。
Objective To investigate the correlation between signal characteristics of magnetic resonance imaging （MRI） T2WI and the expression of proliferating cell nuclear antigen （Ki-67） in breast cancer. Methods A total of 122 cases of breast cancer in our hospital were selected from September 2011 to April 2017 with a retrospective study of random sampling method. T2WI signals characteristics and DWI ADC values of breast cancer were recorded, immunohistochemical detection of Ki-67 was done. Results The positive rate of Ki-67 in cancer and adjacent tissues was 54.9% and 23.8%, respectively. The positive rate of Ki-67 in cancer tissues was higher than that in adjacent tissues （P 〈 0.05）. T2WI signal characteristics of the cancer tissues （78 cases, 63.9%） were mainly high or high light signals, while were mainly low or equal ones for adjacent tissues （9 cases, 7.4%） . The ADC value in cancer tissues was （0.89 ± 0.12 × 10-3/mm2）, which was lower than that （1.67 ± 0.24 × 10-3/mm2） in the adjacent tissues （t = 10.382, P 〈 0.05）. In cancer tissues, Spearman correlation coefficient analysis showed there was positive correlation between T2WI high signal and Ki-67 positive rate （rs = 0.724, P 〈 0.05）, while T2WI high signal was negatively correlated with ADC value （rs = -0.452, P 〈 0.05）. Multivariate analysis showed that the T2WI high signal and ADC value were also the independent risk factors of Ki-67 positive rate （P 〈 0.05）. Conclusion In breast cancer, signal of MRI T2WI is mostly high; expression rate of Ki-67 is high and is negatively correlated with ADC. T2WI signal characteristics can be used for breast cancer screening and prognosis.
作者
吴健
Jian Wu(Department of Radiology,Sanya People＇s Hospita,Sanya,Hainan 572000,China)
出处
《中国现代医学杂志》
CAS
2018年第24期119-123,共5页
China Journal of Modern Medicine
关键词
磁共振
乳腺癌
T2WI信号特征
细胞核增殖抗原
magnetic resonance imaging
breast cancer
T2WI signal proliferating cell
nuclear antigen
