摘要
目的消瘀泄浊饮对糖尿病肾病(DN)慢性肾脏病(CKD)3~5期患者血清瘦素(LP)干预作用。方法按随机原则将80例DN CKD3~5期患者分为治疗组和对照组,每组各40例。对照组予以西医常规治疗;治疗组在对照组基础上采用消瘀泄浊饮治疗,1剂/d,两组疗程均为3个月。检测治疗前后LP进行主要症状评分。结果两组治疗后LP下降,治疗组LP水平低于对照组(P<0.05);治疗组治疗后主要症状、体征积分低于对照组(P<0.05)。结论在西医常规基础上,消瘀泄浊饮对DN CKD3~5期患者肾功能有一定的保护作用,延缓肾衰竭的进程。
Objective To investigate the effect of Xiaoyuxiezhuoyin on serum leptin （LP） in diabetic patients with CKD3-5 renal failure. Methods Totally 80 diabetic patients with CKD3-5 renal failure were randomly divided into observation group and control group （n = 40）. All patients were treated with standard medical therapy. Patients in observation group received additional Xiaoyuxiezhuoyin （1 dose per day for 3 months）. Concentration of LP was measured priorpre to and post treatment. Main symptom scores were recorded. Results Patients in observation group experienced more dramatical reduction of LP compared with that in control group, though concentration of LP was decreased in control group （P 〈 0.05）. scores of main symptoms and signs in observation group were improved significantly when compared with control group （P 〈 0.01）. Conclusion Xiaoyuxiezhuoyin exerts renal protection in diabetic patients with CKD3-5 kidney failure, alleviating clinical symptoms and progression of renal failure.
作者
柯鹏翔
何灵芝
张培培
Peng-xiang Ke;Ling-zhi He;Pei-pei Zhang(Zhe jiang Chinese Medical University,Hangzhou,Zhejiang 310053,China;Zhejiang Provincial Hospital of TCM,Hangzhou,Zhejiang 310000,China)
出处
《中国现代医学杂志》
CAS
2018年第24期53-56,共4页
China Journal of Modern Medicine
基金
浙江省中医药科学研究基金(No:2016ZA057)
关键词
糖尿病肾病
瘦素
消瘀泄浊饮
diabetic nephropathy
leptin
Xiaoyuxiezhuoyin
