摘要
目的探讨噻托溴铵与孟鲁司特联合治疗对慢性阻塞性肺疾病(COPD)患者的肺功能、痰液炎性细胞及炎性因子表达的影响。方法选取2017年4月~2018年3月我院收治的86例COPD患者,采用随机数字表法将其分为对照组、观察组,每组43例。对照组予以茶碱缓释片口服治疗,研究组予以噻托溴铵联合孟鲁司特治疗。比较两组患者干预前后第一秒用力呼气量(FEV)、肺活量(FVC)、第一秒用力呼气量占肺活量比例(FEV1/FVC)水平、痰液髓过氧化物酶(MPO)、白细胞介素(IL)-8、白三烯B4(LTB4)水平、中性粒细胞以及嗜酸粒细胞水平。结果干预前,两组患者肺功能相关指标的比较,差异均无统计学意义(P>0.05);干预后,两组患者的肺功能相关指标均高于干预前,差异均有统计学意义(P<0.05)。研究组患者的肺功能相关指标均高于对照组,差异均有统计学意义(P<0.05)。干预前,两组患者的痰液炎性因子比较,差异均无统计学意义(P>0.05);干预后,两组患者的痰液炎性因子均低于干预前,差异均有统计学意义(P<0.05),研究组患者的痰液炎性因子均低于对照组,差异均有统计学意义(P<0.05)。干预前,两组患者的诱导痰液炎性细胞比较,差异均无统计学意义(P>0.05);干预后,两组患者的诱导痰液炎性细胞均低于干预前,差异均有统计学意义(P<0.05);研究组患者的诱导痰液炎性细胞均低于对照组,差异均有统计学意义(P<0.05)。结论噻托溴铵联合孟鲁司特治疗COPD可显著改善患者肺功能,降低痰液炎性因子水平,减少痰液炎性细胞。
Objective To investigate the effect of Tiotropium Bromide combined with Montelukast on lung function, inflammatory cells in sputum and expression of inflammatory factors in patients with chronic obstructive pulmonary disease（COPD）. Methods A total of 86 COPD patients admitted to our hospital from April 2017 to March 2018 were selected and divided into control group and observation group with 43 cases in each group by random number table method. The control group was treated with Theophylline Sustained-release Tablets orally, while the study group was treated with Tiotropium Bromide combined with Montelukast. The levels of forced expiratory volume（FEV1）, vital capacity（FVC）, ratio of forced expiratory volume to vital capacity（FEV1/FVC）, sputum myeloperoxidase（MPO）, interleukin（IL）-8, leukotriene B4（LTB4）, neutrophils and eosinophils were compared before and after the intervention.Results Before the intervention, there was no statistical difference between the two groups（P〈0.05）. After the intervention, the lung function related indexes of the two groups were higher than those before the intervention, and the differences were statistically significant（P〈0.05）. The lung function related indexes of the patients in the study group were higher than those of the control group, and the differences were statistically significant（P〈0.05）. Before the intervention, there was no statistically significant difference in sputum inflammatory factors between the two groups（P〈0.05）.After the intervention, the sputum inflammatory factors of the two groups of patients were lower than those before the intervention, the differences were statistically significant（P〈0.05）, and the sputum inflammatory factors of the patients in the study group were lower than those of the control group, the differences were statistically significant（P〈0.05）. Before the intervention, there was no statistically significant difference between the two groups in inducing sputum inflammatory cells�
作者
黄穗华
董敬军
邓杰方
HUANG Sui-hua;DONG Jing-jun;DENG Jie-fang(Department of Respiratory Medicine,Bao＇an District Central Hospital of Shenzhen City,Guangdong Province,Shenzhen 518101,China.)
出处
《中国当代医药》
2018年第23期85-87,94,共4页
China Modern Medicine
关键词
噻托溴铵
孟鲁司特
慢性阻塞性肺疾病
炎性细胞
炎性因子
Tiotropium bromide
Montelukast
Chronic： obstructive pulmonary disease
Inflammatory cells
Inflammatoryfactors
